diphenyl/inflammation

FIELD OF THE INVENTION This invention is in the field of anti-inflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating inflammation and inflammation-associated disorders, such as arthritis. BACKGROUND OF THE INVENTION Prostaglandins play a major

BACKGROUND OF THE INVENTION This invention relates to methods of treating cyclooxygenase mediated diseases and certain pharmaceutical compositions therefor. Non-steroidal, anti-inflammatory drugs exert most of their anti-inflammatory, analgesic and antipyretic activity and inhibit hormone-induced

FIELD OF THE INVENTION The present invention relates to novel diphenyl ether derivatives of formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable

FIELD OF THE INVENTION The present invention relates to novel heterocyclic compounds of the general formula (I), derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, pharmaceutically acceptable salts and pharmaceutically acceptable solvates thereof, and pharmaceutically

BACKGROUND OF THE INVENTION The metabolic routes in which various compounds are biosynthesized from arachidbnic acid, are collectively called the "Arachidonic Acid Cascade." Leukotriene B.sub.4 (LTB.sub.4) is one of many products resulting from the arachidonic acid cascade. Moreover, LTB.sub.4 in

BACKGROUND OF THE INVENTION The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke. The compounds are K-agonists which

BACKGROUND OF THE INVENTION The diphenyl-cyclopropene derivatives of the instant invention are kappa opioids useful in the treatment of pain, inflammation, Parkinsonism, dystonia, cerebral ischemia, diuresis, asthma, psoriasis, irritable bowel syndrome, and stroke. The compounds are K-agonists which

BACKGROUND OF THE INVENTION A. Field of the Invention The present invention relates to substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives and more particularly relates to the novel compounds of formula I which are specific 5-lipoxygenase inhibitors and are useful as anti-inflammatory

BACKGROUND OF THE INVENTION The stilbenes isolated from Photorhabdus species bacteria are known to have antibiotic activity (Paul et al. Journal of Chemical Ecology, 7: 589-597 (1981), and Hu et al., Canadian Journal of Microbiology. 44: 1072-1077 (1998). However, these compounds have not been shown

BACKGROUND Signal Transducer and Activator of Transcription (STAT) proteins are transcription factors that mediate cellular responses to growth factors. These proteins are activated via tyrosine phosphorylation by growth factor receptor-associated tyrosine kinases. Activated STAT proteins promote

BACKGROUND OF THE INVENTION Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin (Ig) supergene family, is expressed on activated, but not resting, endothelium. The integrin VLA-4 (a.sub.4 b.sub.1), which is expressed on many cell types including circulating lymphocytes,

BACKGROUND OF THE INVENTION Vascular cell adhesion molecule-1 (VCAM-1), a member of the immunoglobulin (Ig) supergene family, is expressed on activated, but not resting, endothelium. The integrin VL4 (a.sub.4 b.sub.1), which is expressed on many cell types including circulating lymphocytes,

DETAILED DESCRIPTION OF INVENTION 1. Technical Field The present invention relates to novel 4-aryl pyridine derivatives, processes for preparing them and pharmaceutical preparations containing them. The 4-aryl pyridine derivatives of the present invention inhibit I.kappa.B kinase .beta. (IKK-.beta.

The invention relates to pharmaceutical compositions containing liopxygenase- and prostaglandin H synthase-inhibiting active ingredients for preferably topical application in human and veterinary medicine. They are used in particular for the treatment of inflammatory skin diseases of non-microbial

FIELD OF THE INVENTION The instant invention involves compounds that inhibit 5-lipoxygenase activating protein (FLAP), compositions containing such compounds and methods of treatment using such compounds for the treatment and prevention of atherosclerosis and related diseases and