Omega-3 group (n=30) received capsules containing 945 mg of Omega-3 PUFA [α linolenic acid/ 64%, eicosapentaenoic acid (EPA)/16% and docosahexaenoic acid (DHA)/21%], in 3 capsules/ day

Fatty Liver

Omega 3

University of Sao Paulo School of Medicine

Omega 3 Supplementation in Fatty Liver

Polyunsaturated Fatty Acid (Pufa) Omega 3 in the Reduction of the Inflammatory Component of the Nonalcoholic Steatohepatitis (Nash):Randomized Placebo Controlled Study

Determine the efficacy of Omega-3 fatty acid in reducing the inflammatory component of NASH for liver through liver biopsy NAS score.

Measure TNFalfa, IL6, adiponectin, lipidic leuckocyte profile, EPA (eicosapentaenoic acid), DHA (docosahexaenoic) and laboratory tests AST, ALT, Cholesterol, total triglycerides, PCR, VHS, SAA.

Claudia Pinto Marques Oliveira

University of Sao Paulo General Hospital

control period with no intervention. Comparison of parameters at entrance and one month later without any intervention

Mediterranean diet prescription during 3 months

Subjects will be trained 3 times a week during 3 months

Both a dietary prescription plus exercise training during 3 months

Metabolic Syndrome

Analysis at recruitment and after a month without any intervention

Control period

selected subjects will adopt a Mediterranean low-AGE diet. We will not include red wine in the Mediterranean diet (7 Kilocalories (KCal)/g), in order to attain more weight loss. Each subject will be instructed to reduce 500 Kcal of their estimated total daily energy requirements, so theoretically they will be able to reduce 5 - 10 % of their body weight in 3 months.

Diet Group

The intervention will consist of 3 weekly 1 hour sessions (5 minutes of preconditioning, followed by 20 minutes cycling, brisk walking or jogging at 65-70 % maximal aerobic capacity, then 25 minutes resistance weight-lifting exercises and finally 10 minutes of stretching). Exercise intensity will be increased weekly according to the Borg Scale intensity. The exercise intervention will be supervised by physical education teachers, registering attendance at every session.

Exercise group

these patients will be incorporated to receive both Mediterranean diet plus exercise interventions

Diet + Exercise

Institute of Nutrition & Food Technology (INTA)

Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue

Mitochondrial Biogenesis, Reduction of Muscle Oxidative Damage and Improvement in Adipose Tissue Functional Profile, Account for the Beneficial Effects of Exercise and Healthy Diets

MARIA PIA DE LA MAZA

Professor

University of Chile

Fondo Nacional de Desarrollo Científico y Tecnológico, Chile

After a placebo phase with no intervention in the first 25 subjects recruited, overweight or obese patients were randomly assigned to one of 3 treatments: hypocaloric diet, high intensity interval training or both interventions simultaneously, for 3 months.

formaldehyde/obesity

Omega 3 Supplementation in Fatty Liver

Beneficial Effects of Exercise and Healthy Diets on Muscle and Adipose Tissue

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