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An Alternative Pathway for Formononetin Biosynthesis in Pueraria lobata.

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The O-methylation is an important tailing process in Pueraria lobata isoflavone metabolism, but the molecular mechanism governing it remains not elucidated. This manuscript describes the mining of key O-methyltransferases (OMTs) involved in the process. Using our previously constructed P. lobata

Potential Anticancer Properties and Mechanisms of Action of Formononetin.

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Nature, a vast reservoir of pharmacologically active molecules, has been most promising source of drug leads for the cure of various pathological conditions. Formononetin is one of the bioactive isoflavones isolated from different plants mainly from Trifolium pratense, Glycine max, Sophora

The Stimulatory Effect of Strontium Ions on Phytoestrogens Content in Glycine max (L.) Merr.
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The amount of secondary metabolites in plants can be enhanced or reduced by various external factors. In this study, the effect of strontium ions on the production of phytoestrogens in soybeans was investigated. The plants were treated with Hoagland's solution, modified with Sr(2+) with

Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC.
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BACKGROUND The risks of hormone replacement therapy have led to a search for new alternatives such as phytoestrogens, plant compounds with estrogen-like biological activity. Isoflavones are the phytoestrogens most extensively studied and can be found in soybean, red clover and other plants. Due to

Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes.
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BACKGROUND Isoflavones and coumestrol from dietary legumes are plant constituents showing multiple beneficial effects on humans. Owing to their ability to bind with mammalian estrogenic receptors and thereby intervention in several kinds of hormone-related cancers, they have received much attention.

Isoflavone Content in Subterranean Clover Germplasm from Sardinia.
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Subterranean clover (Trifolium subterraneum) is an important pasture legume, and Sardinia is known as a major centre of diversification of this species. As other legumes, this clover produces biologically active flavonoids including the subclass of isoflavones that are natural phytoestrogens with

HPLC/DAD/MS and antioxidant activity of isoflavone-based food supplements.
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Isoflavones are polyphenolic compounds found mainly in legumes the benefits of which have been widely studied and attributed in particular to their phytoestrogenic activity. The aim of this study was to evaluate the quali-quantitative composition of food supplements based on soy isoflavones (Glycine

Ultrahigh-pressure liquid chromatography of isoflavones and phenolic acids on different stationary phases.
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Complete separation of aglycones and glucosides of selected isoflavones (genistin, genistein, daidzin, daidzein, glycitin, glycitein, ononin, sissotrin, formononetin, and biochanin A) was possible in 1.5 min using an ultrahigh-pressure liquid chromatography (U-HPLC) on a different particular

Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy.
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Extracts from red clover (Trifolium pratense), soybean (Glycine max.) and black cohosh (Cimicifuga racemosa) are frequently used as alternative compounds for hormone replacement therapy (HRT) to treat menopausal disorders. Fifteen commercially available products made either from red clover, soybean

Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli.
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Flavonoids found in plants most likely undergo a variety of modification reactions such as hydroxylation, glycosylation, and/or methylation. Among these, O-methylation has an effect on the solubility and thus on the antimicrobial activity of the flavonoids. We analyzed the conversion of naringenin

Inducible De Novo Biosynthesis of Isoflavonoids in Soybean Leaves by Spodoptera litura Derived Elicitors: Tracer Techniques Aided by High Resolution LCMS.
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Isoflavonoids are a characteristic family of natural products in legumes known to mediate a range of plant-biotic interactions. For example, in soybean (Glycine max: Fabaceae) multiple isoflavones are induced and accumulate in leaves following attack by Spodoptera litura (Lepidoptera: Noctuidae)

Transcriptional and Chemical Changes in Soybean Leaves in Response to Long-Term Aphid Colonization.
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Soybean aphids (Aphis glycines Matsumura) are specialized insects that feed on soybean (Glycine max) phloem sap. Transcriptome analyses have shown that resistant soybean plants mount a fast response that limits aphid feeding and population growth. Conversely, defense responses in

Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis.
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Isoflavonoids are ecophysiologically active secondary metabolites of the Leguminosae and known for health-promoting phytoestrogenic functions. Isoflavones are synthesized by 1,2-elimination of water from 2-hydroxyisoflavanones, the first intermediate with the isoflavonoid skeleton, but details of

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formononetin/ダイズ

An Alternative Pathway for Formononetin Biosynthesis in Pueraria lobata.

Potential Anticancer Properties and Mechanisms of Action of Formononetin.

The Stimulatory Effect of Strontium Ions on Phytoestrogens Content in Glycine max (L.) Merr.

Effects of phytoestrogens derived from soy bean on expression of adhesion molecules on HUVEC.

Distribution of isoflavones and coumestrol in neglected tropical and subtropical legumes.

Isoflavone Content in Subterranean Clover Germplasm from Sardinia.

HPLC/DAD/MS and antioxidant activity of isoflavone-based food supplements.

Ultrahigh-pressure liquid chromatography of isoflavones and phenolic acids on different stationary phases.

Comparison of hormonal activity (estrogen, androgen and progestin) of standardized plant extracts for large scale use in hormone replacement therapy.

Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli.

Inducible De Novo Biosynthesis of Isoflavonoids in Soybean Leaves by Spodoptera litura Derived Elicitors: Tracer Techniques Aided by High Resolution LCMS.

Transcriptional and Chemical Changes in Soybean Leaves in Response to Long-Term Aphid Colonization.

Molecular and biochemical characterization of 2-hydroxyisoflavanone dehydratase. Involvement of carboxylesterase-like proteins in leguminous isoflavone biosynthesis.

科学に裏打ちされた最も完全な薬草データベース