heparin/inflammation

CROSS-REFERENCE TO RELATED APPLICATIONS This application is a National Phase application under 35 U.S.C. .sctn.371 of International Application No. PCT/GB2010/001780 filed Sep. 21, 2010 and claims the benefit of Great Britain Application No. 0916578.8 filed Sep. 22, 2009, the disclosures of which

BACKGROUND OF THE INVENTION Glycosaminoglycans, a ubiquitous class of sulfated polysaccharides, play a critical role in various physiological processes, such as development, wound healing, angiogenesis, cell division, inflammation and spinal cord injury. The complexity of this class of natural

FIELD OF THE INVENTION This invention relates to O-desulfated heparin compositions and methods of making the same, preferably 6-O-desulfated heparin compositions, wherein the methods permit regulating the degree of 6-O-desulfation. The compositions are useful for treating various diseases, including

This application is the U.S. national phase of international application PCT/EP02/13651, filed 3 Dec. 2002, which designated the U.S. The present invention relates to pharmaceutical compositions suitable for the oral administration of heparin or derivatives thereof for the treatment of inflammatory

The present invention relates to pharmaceutical compositions suitable for the oral administration of heparin or derivatives thereof, for example dalteparin, salts and/or derivatives thereof, for the treatment of inflammatory bowel diseases. More particularly, the invention relates to

FIELD OF THE INVENTION This invention is in the field of medical treatments and is directed to the use of heparinase enzyme as a treatment or prophylactic for reducing localized inflammatory responses. BACKGROUND OF THE INVENTION An inflammatory response is local response to cellular injury that is

BACKGROUND OF THE INVENTION The adhesion of mammalian cells to the extracellular matrix is of fundamental importance in regulating growth, adhesion, motility and the development of proper cellular phenotype. This has implications for normal development, wound healing, immunity, chronic inflammatory

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles supplement those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1) [Applicant Cerami

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles supplement those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1) [Applicant Cerami

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles supplement those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1) [Applicant Cerami

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles are in supplementation to those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1)

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles are in supplementation to those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1)

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles are in supplementation to those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1)

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles are in supplementation to those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1)

RELATED PUBLICATIONS The Applicants are authors or co-authors of several articles directed to the subject matter of the present invention. These articles are in supplementation to those articles listed in U.S. Pat. No. 4,603,106, which earlier articles are incorporated herein by reference. (1)