Healthy subjects with no respiratory disease and never smokers

Healthy subjects without respiratory disease and at least a cumulative tobacco consumption history of <10 pack-years

COPD patients (diagnosed as recommended by GOLD 2017 strategy) former or current smokers with at least >10 pack-years

COPD

COPD Exacerbation

COPD, Severe Early-Onset

Blood samples from healthy volunteers will be collected in EDTA tubes (Vacutainer, BD Bioscience). CPC will be isolated according to previous patented method (P201730724)

Isolation of Circulating Pulmonary Cells in peripheral blood

Hospital de Alta Resolución de Loja

Hospital Universitario de Torrecardenas

Universidad de Granada- Facultad de Medicina

GENYO, centro Pfizer- Universidad de Granada- Junta de Andalucía de inestigación genómica y oncológica

Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes (IbICEnCa)

Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes.

Enrique Herrera Viedma

Vice-Rector for Research and Transfer

Universidad de Granada

Hospital de Alta Resolucion de Loja. Agencia Sanitaria Hospital de Poniente

Genyo-CentroPfizer-UGR-Junta Andalucia de genomica e investigacion oncologica

Patients with diagnosis of LCH based on histopathological or clinical and radiological findings.

Current or ex smokers matched with cases for age, gender and smoking history.

Langerhans Cell Histiocytosis

InCor Heart Institute

Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis

Evaluation of Exercise Capacity and Mechanisms of Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis

Maximal O2 uptake capacity (VO2 max) during a cardiopulmonary exercise test (mL/kg/min)

Distance during a six-minute walk test in meters

SF-36 questionnaire to evaluate quality of life

Diffusing capacity for carbon monoxide (mL/min/mmHg)

Serial measurement of inspiratory capacity during incremental cardiopulmonary exercise test (L)

FEV1 (Pulmonary lung function - spirometry) - L

Velocity measurement of tricuspid regurgitant jet evaluated by transthoracic echocardiography (m/s)

Residual volume/total lung capacity ratio evaluated in pulmonary lung function - plethysmography

Residual volume evaluated in pulmonary lung function - plethysmography (L)

Desaturation during a six-minute walk test (%)

Ejection fraction evaluated by transthoracic echocardiography (%)

Diameter of the cardiac chambers evaluated by transthoracic echocardiography (cm)

Bruno Guedes Baldi

All patients underwent extensive evaluation:
- Body composition, Diabetes; dyslipidemia, hemoconcentration, hypertension, exercise capacity: 6-Minute Walk test procedure, renal function, inflammatory markers, cause and place of death, time tracking concentrator, quality of life and pulmonary Function.

Chronic Obstructive Pulmonary Disease and Allied Conditions

The Global Initiative for Chronic Obstructive Lung Disease (GOLD) works with health care professionals and public health officials to raise awareness of Chronic Obstructive Pulmonary Disease (COPD) and to improve prevention and treatment of this lung di

Predictors of Mortality in Patients With Advanced Lung Disease in Home Oxygen Therapy

Evaluate the results of evaluations carried out in patients who died and had advanced lung disease diagnosis in use of home oxygen, compared to patients who did not die and the normal population

Assess the amount of oxygen that was used by patients during treatment indication and measurement of variable

Measure the quality of life of these patients and compared with the normal population and patients who died and had survival for longer period

Search the causes of death of these patients and the place to compare with the current epidemiology and relate to the main disease

idiopathic pulmonary fibrosis/ニコチン

Isolation of Circulating Pulmonary Cells in COPD and Its Relationship With Clinical Relevant Outcomes (IbICEnCa)

Evaluation of Exercise Capacity and Exercise Limitation in Patients With Pulmonary Langerhans Cell Histiocytosis

Predictors of Mortality in Patients With Advanced Lung Disease in Home Oxygen Therapy

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