neurodegenerative diseases/edema

RELATED APPLICATIONS This is a US national phase filing under 35 U.S.C. .sctn. 371 of PCT/JP02/13096 filed Dec. 13, 2002 and claims priority from JP 2001-382174 filed Dec. 14, 2001 and JP 2002-200556 filed Jul. 9, 2002. TECHNICAL FIELD The present invention relates to a screening method and

CROSS-REFERENCE TO RELATED APPLICATIONS This application is the 35 U.S.C. .sctn.371 national stage of PCT application PCT/JP2005/007354, filed Apr. 11, 2005, which claims priority to Japanese patent application No. 116725/2004, filed Apr. 12, 2004. The contents of these applications are incorporated

INDUSTRIAL FIELD OF THE APPLICATION The present invention relates to novel N,N-substituted cyclic amine compounds useful as a calcium antagonist, particularly as a nerve-selective calcium antagonist, specifically as an agent for treating and improving the diseases against which an inhibitory action

CROSS REFERENCE TO RELATED APPLICATION The present invention is based on, and claims priority from 60/008,390, filed Dec. 8, 1995. BACKGROUND OF THE INVENTION This application is directed to inhibitors of nitric oxide synthase, and in particular substituted azacycle derivatives. Nitric Oxide in

BACKGROUND OF THE INVENTION This application is directed to inhibitors of Nitric oxide synthase, and in particular cyclic amidines. Nitric Oxide in Biology. The emergence of nitric oxide (NO), a reactive, inorganic radical gas as a molecule contributing to important physiological and pathological

BACKGROUND OF THE INVENTION Certain adamantane derivatives have been used to treat illnesses. Rimantadine (1-(1-aminoethyl)adamantane) is used for the prophylaxis and treatment of influenza in humans. Amantadine has been used for the treatment of both influenza and Parkinson's disease (Schwab et

BACKGROUND OF THE INVENTION Certain adamantane derivatives have been used to treat illnesses. Rimantadine (1-(1-aminoethyl)adamantane) is used for the prophylaxis and treatment of influenza in humans. Amantadine has been used for the treatment of both influenza and Parkinson's disease (Schwab et

BACKGROUND OF THE INVENTION Certain adamantane derivatives have been used to treat illnesses. Rimantadine (1-(1-aminoethyl)adamantane) is used for the prophylaxis and treatment of influenza in humans. Amantadine has been used for the treatment of both influenza and Parkinson's disease (Schwab et

TECHNICAL FIELD The present invention relates to a nootropic agent which comprises a derivative of 2-phenyl-3-oxo-2H-1,4-benzothiazine, for instance, a nootropic agent which is effective in treating or presenting diseases accompanied by a lowering of cerebral functions such as cerebral infarction

TECHNICAL FIELD The present invention relates to quinolinomorphinan derivatives or pharmacologically acceptable acid addition salts thereof, and an agent for curing or preventing worsening of cerebral disorders comprising one of the derivatives or salts thereof, and particularly to a medicine useful

CROSS REFERENCE TO RELATED APPLICATIONS This application is a 371 of PCT/JP98/00092 filed Jan. 13, 1998 now WO98/31684 and claims priority of Japanese Application No. 5829, filed Jan. 16, 1997. TECHNICAL FIELD The present invention relates to indolomorphinan derivatives or pharmacologically