ototoxicity/ニコチン

Radiotherapy and cisplatin lead to cell killing in head and neck squamous cell carcinoma patients, but adverse events and response to treatment are not the same in patients with similar clinicopathological aspects. The aim of this prospective study was to evaluate the roles of TP53 c.215G

Nicotine administered in high doses intravenously (1 mg/kg) and intracochlearly (10 mM) exhibited very little effect on guinea pig cochlear potentials. When administered chronically (1-20 mg/kg, i.p. for 20 days), nicotine demonstrated no effect on cochlear potentials or the number of observed hair

Many factors determine individual susceptibility to toxic agents in addition to their primary interaction with the target site. Absorption, delivery to target tissues, bio-activation, bio-inactivation, elimination, and adaptive or protective responses all play important parts in determining the