compare experimental group to controlled group

Liver Dysfunction

Red ginseng

ChuncheonSHH

Effects of Red Ginseng on Liver Function

Effect of Korea Red Ginseng on Non-alcoholic Fatty Liver Disease

Ki Tae Suk

Proffesor

Chuncheon Sacred Heart Hospital

LUOTAI group treated with LUOTAI with dosage, dosing schedule and duration follows local clinical practice in accordance with the terms of the local marketing authorization: 400mg of LUOTAI injectable lyophilized powder diluted in 250ml of 5% Glucose Solution or 0.9% Normal Saline for included diabetic patients, via slow intravenous infusion, once daily for consecutive 14 days, and followed by 200mg of LUOTAI soft capsules, three times a day for 65 days.

Control group comprises of patients who are not treated with LUOTAI, and follows local clinical practice for ischemic stroke.

Infarction, Anterior Cerebral Artery

Infarction, Middle Cerebral Artery

Ischemic Attack, Transient

Bach Mai Hospital

Phu Tho General Hospital

103 Military Hospital

An Observational Registry Study of LUOTAI in Patients With Acute Ischemic Stroke in Vietnam

A Non-interventional, Controlled, Open-label, Observational Registry Study to Investigate the Safety and Effectiveness of LUOTAI (Panax Notoginseng) Injectable and Soft Capsules in Patients With Acute Ischemic Stroke in Vietnam

Modified Rankin Scale (mRS) is an overall functional outcome measure, measuring stroke defect. Answer the test questions for 5-10 minutes. The score range is 7 points with a score of 0 for the absence of sequelae and the worst possible score is 6.
0 - No symptoms.
- No significant disability. Able to carry out all usual activities, despite some symptoms.
- Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.
- Moderate disability. Requires some help, but able to walk unassisted.
- Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.
- Severe disability. Requires constant nursing care and attention, bedridden, incontinent.
- Dead. Primary Efficacy Endpoint defined as "Categorical shift in mRS score at 3 months (ordinal logistic regression analysis of the mRS on Day 90)".

Ordinal NIHSS at 3 months after stroke onset

Ordinal MoCA at 3 months after stroke onset

Proportion of patients with excellent recovery and functional dependence at 3 months after stroke onset (mRC=0 or 1)

KPC Pharmaceuticals, Inc

sanchitongshu 1 capsule each time ,three times a day and Aspirin 75mg for 90 days ; placebo of clopidogrel 75mg daily for 21 days after randomization

placebo of sanchitongshu1 capsule each time ,three times a day and Aspirin 75mg for 90 days;clopidogrel 75mg per day for 21 days after randomization

Stroke, Acute

The study drugs were manufactured according to Good Manufacturing Practice (GMP) by the Pharmaceutical Factory of Chengdu Huasun Group Inc. Ltd. and presented in the form capsules. Every Sanchitongshu capsule weighed 200 mg, contained 100 mg of panaxatriol saponin (PTS) and 100 mg inactive excipient (starch). PTS comprised of dried extracts from roots of Radix Notoginseng, and had been standardised with respect to Ginsenoside Rg1 (50%), Ginsenoside Re (6%), Notoginsenoside R1 (11%). The amounts of the active ingredients were determined by analytical RP-HPLC using an acetonitrile-water gradient system as mobile hase. The peaks were detected by UV-DAD.

Sanchitongshu

The Sanchitongshu placebo capsule contained dark brown muscovado sugar and the same inactive excipient (starch).

placebo of Sanchitongshu

Aspirin

Clopidogrel

placebo of clopidogrel

Sanchitongtshu Plus Asprine for Minor Ischemic Stroke or Transient Ischemic Attack: A Randomized Double-blind Study

Radix/Rhizoma Notoginseng Extract (Sanchitongtshu) Plus Asprine for Minor Ischemic Stroke or Transient Ischemic Attack: A Randomized Double-blind Placebo-controlled Study

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Comply to the Chinese guidlines of acute ischemic stroke in 2014

Treat with KDZ injection on the basis of basic treatment

Treat with Xueshuantong injection on the basis of basic treatment

Treat with both KDZ injection and Xueshuantong injection on the basis of basic treatment

Ischemic Stroke

KDZ40ml+0.9%N.S.250ml,ivdrip,qd of each 14-day cycle.Number of cycles:one.

Ixeris of sonchifolia Hance

Xueshuantong450mg+0.9%N.S.250ml,ivdrip,qd of each 14-day cycle.Number of cycles:one.

Panax notoginseng saponins

KDZ40ml+0.9%N.S.250ml,ivdrip;Xueshuantong450mg+0.9%N.S.250ml,ivdrip,qd of each 14-day cycle.Number of cycles:one.

panax ginseng/抗炎症薬

Effects of Red Ginseng on Liver Function

An Observational Registry Study of LUOTAI in Patients With Acute Ischemic Stroke in Vietnam

Sanchitongtshu Plus Asprine for Minor Ischemic Stroke or Transient Ischemic Attack: A Randomized Double-blind Study

Heat-clearing and Blood-activating Chinese Medicinal Components in Acute Cerebral Infarction

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