paraproteinemias/プロリン

A 56-year-old man with chronic hepatitis was admitted to the nephrology unit because of a progressive increase in serum creatinine(Cr). Blood Urea Nitrogen(BUN) and Cr, measured by the enzymatic method, were 15 and 2.0 mg/dl, respectively, in 1999, and changed to 17 and 3.8 mg/dl, respectively, on

A patient is described with typical skin lesions of lichen myxedematosus and IgG-type lambda paraproteinemia. Fibroblasts cultured from the skin of the patient and from the skin of control persons were used to study glycosaminoglycan and collagen synthesis; the cultures were labelled with

Next-generation sequencing has revealed cancer genomic landscapes, in which over 100 driver genes that, when altered by intragenic mutations, can promote oncogenesis. MYD88 is a driver gene found in hematologic B-cell malignancies. A missense mutation (L265P) changing leucine at position 265 to

Cases of low-grade B-cell lymphoma presenting primarily in the bone marrow are rare, and its clinicopathology remains unclear. We retrospectively examined patients with low-grade B-cell lymphoma presenting primarily in the bone marrow. Fourteen patients met the inclusion criteria, including 5 with