A method for evaluating a compound to determine the relative or absolute therapeutic capability of a compound to pharmacologically inhibit ischemia induced activation of iPLA.sub.2.beta. in an intact myocardium which comprises treating intact myocardium with a compound, inducing ischemia in the myocardium tissue and determining if there has been a change in expression of iPLA.sub.2.beta., its activity or in the iPLA.sub.2.beta. regulating network and determining if there has been a change then that the compound is an anti-arrhythmia or myocardial salvage drug.

Washington University in St. Louis

Calcium-independent phospholipase A2 induces ischemic ventricular arrhythmias and decreases infarction size

Aromatic sulfonamide derivatives, particularly benzenesulfonamide, 4-fluorobenzenesulfonamide, 5-chloro-1-naphthalenesulfonamide and 5-isoquinolinesulfonamide derivatives are provided that inhibit Ca.sup.2+ -dependent enzymes and proteins such as Phospholipase A.sub.2, protein kinases such as Protein Kinase C, and inhibit membrane fusion, thereby being a valuable drug for the treatment of inflammation, arthritis, infarction, nephritis and many other types of tissue injury.

Pharno-Wedropharm GmbH

Aromatic sulfonamide derivatives, their use as enzyme inhibitors and pharmaceutical compositions containing them

This invention relates to chemical compounds which possess valuable therapeutic activity particularly as lipoxygenase and phospholipase C inhibitors and as platelet-activating factor receptor antagonists. The compounds posses anti-inflammatory anti-asthmatic and anti-allergic properties and are additionally useful for the treatment of myocardial infarctions. The compounds of this invention are imidazolino-containing compounds of the general formula: ##STR1##

phospholipase/infarction

Calcium-independent phospholipase A2 induces ischemic ventricular arrhythmias and decreases infarction size

Aromatic sulfonamide derivatives, their use as enzyme inhibitors and pharmaceutical compositions containing them

Bis-imidazolinoamino derivatives as antiallergy compounds

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