Anogenital warts (AGW) are a common therapeutic challenge. All therapies are associated with burning, pain and frustrating high rate of recurrence. The search for a new alternative continues. Recently a diterpene ester extracted from the Euphorbia Peplus plant (Ingenol mebutate (IM))
The irritant and cytotoxic constituents of the latex of Euphorbia paralias L. were separated from the hydrocarbon fraction by means of solvent partition. 3 new ingenane esters were identified from the toxic ether fraction. The major compound was 3-angelyl-20-deoxyingenol and the 2 minor compounds