prolactinoma/プロリン

We have studied the effects of the TRH related dipeptide histidyl-proline diketopiperazine [cyclo (His-Pro)] on basal and stimulated TSH and PRL secretion in normal volunteers, in patients with microprolactinomas and in patients with primary hypothyroidism. Cyclo (His-Pro), 400 micrograms

Gene expression profiles of prolactinomas were compared with those of normal pituitary glands to identify differentially expressed genes (DEGs). Protein-protein interaction (PPI) analysis and protein complex prediction were performed to reveal the cross-talk between these genes and molecular

OBJECTIVE To report a new mutation of the multiple endocrine neoplasia type 1 (MEN1) gene in an Italian kindred. METHODS The study included the female proband, aged 50 years, affected by primary hyperparathyroidism, insulinoma and prolactinoma, and ten relatives. Blood samples were obtained for

Pituitary tumor-transforming gene (PTTG) originally isolated from GH-secreting pituitary adenoma cells causes in vitro cell transformation, in vivo tumorigenesis, and induces basic fibroblast growth factor. These functions require an intact C-terminal proline-proline-serine-proline motif. PTTG1 is