pteris linearis/悪性腫瘍

OBJECTIVE To investigate the apoptosis-inducing effect of Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), a compound isolated from Pteris semipinnata L (PsL), on human gastric cancer SGC7901 cells and explore its mechanism. METHODS The inhibitory effect of 5F on SGC7901 cells was observed by MTT

OBJECTIVE To examine the apoptotic effect of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), a compound isolated from Pteris semipinnata L (PsL), in human lung cancer A549 cells. METHODS A549 cells were treated with 5F (0-80 μg/ml) for different time periods. Cytotoxicity was examined using a

Two-drug combination chemotherapy, often including cisplatin and one other drug, remains the standard of care for patients with advanced non-small cell lung cancer (NSCLC). To improve the treatment of late-stage NSCLC and decrease the toxicity of combination chemotherapy, the search for novel drugs

Neoplastic lesions were induced in 10 out of 58 experimental toads (Bufo regularis) force-fed with alpha-ecdysone, which naturally occurs in the leaves of bracken fern (Pteris aquilina). The results of this study prove that alpha-ecdysone may be one of the factors responsible for the carcinogenicity

Alpha ecdysone is naturally present in the leaves of some plants, including the carcinogenic plant bracken fern (Pteris aquilina). Feeding mice with alpha-ecdysone at a dose level of 3 ppm/25 g body weight, 2 times per week for 22 months induced a significant increase in the body weight of the

The carcinogenic effect of bracken fern (Pteris aquilina) to the urinary bladder of mice was studied. Powdered bracken fern mixed with a basic commercial diet (1:4 by weight) was fed to a group of 40 ICR strain mice for 20 weeks after the implantation of a glass bead into the bladder. A total

Two new pterosin glycosides, (2S,3S)-pterosin C 3-O-β-d-(4'-(E)-caffeoyl)-glucopyranoside (1) and (2S,3S)-pterosin C 3-O-β-d-(6'-(E)-p-coumaroyl)-glucopyranoside (2), were isolated from Pteris multifida (Pteridaceae) roots along with ten known pterosin compounds (3-12). The chemical structures of

Previous studies have demonstrated strong anti-tumor effects of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), an extract from Pteris semipinnata, in liver, lung, stomach and anaplastic thyroid cancer cells. However, whether 5F inhibits the growth of breast cancer cells remains unclear. The

Ent-11 alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), an antitumor component, is a chemical compound isolated from Pteris semipinnata L (PsL), a Chinese traditional herb. We examined whether 5F could affect apoptosis in human colon cancer HT-29 cells, and test whether and how the over-expression

Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) is a chemical compound isolated from Pteris semipinnata L (PsL), a Chinese traditional herb. 5F has been known to exert antitumor activity in several kinds of human malignant cancer cells by leading cancer cell to apoptosis. 5F translocated Bax into

The objective of this paper was to investigate the inhibitory effect of total flavonoids from Pteris multifida Poir on growth of transplanted H22 tumour in mice. H22 tumour-bearing mice model was established; the experimental animals were divide/d into the model group, Pteris multifida Poir total

In this study, we demonstrated that Ent-11alpha-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F) had stronger cytotoxicity against MKN-45, a gastric cancer cell line bearing wild-type p53 than MKN-28, another gastric cancer cell line containing missense mutation in p53. The rapid increase of ROS level was

Pteris vittata L. from the foothills of Kangra district, Himachal Pradesh, India has been investigated for its potential to combat reactive oxygen species and DNA damaging agents. DPPH radical, superoxide anion radical, ABTS(+.) radical cation decolorization, reducing power, deoxyribose degradation,

Breast cancer is the most common cancer worldwide that costs lives of millions of people every year. Plant products with potential anticancer activities have become a vital source of novel agents in treating cancer. Adiantum capillus veneris (ACV) and Pteris Quadriureta (PQ) are such traditional

The dried whole plant of Pteris dispar were milled and extracted with 95% EtOH. The resulting dried extract was isolated by kinds of chromatographic column, including polyamide, Sephadex LH-20, preparative HPLC. As a result, ten diterpenes were isolated from the plant. By analyzing of ESI-MS and NMR