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ページ 1 から 35 結果
Method for treating cancer using monoclonal antibodies
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The present invention relates to a method for obtaining and selecting monoclonal antibodies using an assay of the ADCC type, said antibodies being capable of activating Fc.gamma. type III receptors. The invention is also directed toward monoclonal antibodies having a particular glycan structure, the
Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
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TECHNICAL FIELD OF THE INVENTION
This invention relates to isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH; SEQ ID NOS: 1 and 15) and analogs thereof as well as compositions comprising CEFH peptides and analogs thereof. The CEFH peptides disclosed herein are
Amino O-aryl macrolides having immunosuppressive activity
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SUMMARY OF THE INVENTION
The present invention is related to amino O-aryl macrolides and derivatives which are useful in a mammalian host for the treatment of autoimmune diseases (such as juvenile-onset or recent-onset diabetes mellitus, multiple sclerosis, rheumatoid arthritis, liver disease,
Alkylidene macrolides having immunosuppressive activity
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SUMMARY OF THE INVENTION
The present invention is related to alkylidene macrolides which are useful in a mammalian host for the treatment of autoimmune diseases (such as juvenile-onset diabetes mellitus, multiple sclerosis and rheumatoid arthritis), immunodepression, infectious diseases and/or the
Alkyl and alkenyl macrolides having immunosuppressive activity
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SUMMARY OF THE INVENTION
The present invention is related to alkyl and alkenyl macrolides which are useful in a mammalian host for the treatment of autoimmune diseases (such as juvenile-onset diabetes mellitus, multiple sclerosis and rheumatoid arthritis), immunodepression, infectious diseases
O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
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The present invention is related to O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides which are useful in a mammalian host for the treatment of autoimmune diseases (such as juvenile-onset or recent-onset diabetes mellitus, multiple sclerosis, rheumatoid arthritis, liver disease, posterior uveitis,
Quinoline derivitives and their uses
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The present invention relates generally to phosphatidylinositol 3-kinase (PI3K) enzymes, and more particularly to selective inhibitors of PI3K activity and to methods of using such materials.
BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a
Quinolines for the treatment of PI3K-.delta. mediated diseases
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BACKGROUND OF THE INVENTION
The present invention relates generally to phosphatidylinositol 3-kinase (PI3K) enzymes, and more particularly to selective inhibitors of PI3K activity and to methods of using such materials.
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a
Substituted quinolines and their uses in treatment of inflammatory and related conditions
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The present invention relates generally to phosphatidylinositol 3-kinase (PI3K) enzymes, and more particularly to selective inhibitors of PI3K activity and to methods, of using such materials.
BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a
Thrombopoietin mimetics
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FIELD OF THE INVENTION
The present invention is directed to novel thrombopoietin mimetics that are useful as promoters of stem cell growth, thrombopoiesis and megakaryopoiesis.
BACKGROUND OF THE INVENTION
Thrombopoietin (TPO) is the primary physiological regulator of thrombopoiesis, which is the
Thrombopoietin mimetics
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FIELD OF THE INVENTION
The present invention is directed to novel thrombopoietin mimetics that are useful as promoters of stem cell growth, thrombopoiesis and megakaryopoiesis.
BACKGROUND OF THE INVENTION
Thrombopoietin (TPO) is the primary physiological regulator of thrombopoiesis, which is the
Pyridine-3-carboxyamide derivative
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CROSS-REFERENCE TO RELATED APPLICATION
This application is a National Phase Patent Application and claims the priority of International Application Number PCT/JP2009/070363, filed on Nov. 27, 2009, which claims priority of Japanese Patent Application Number 2008-305054, filed on Nov. 28, 2008,
Heterocyclic compounds and their uses
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The present invention relates generally to phosphatidylinositol 3-kinase (PI3K) enzymes, and more particularly to selective inhibitors of PI3K activity and to methods of using such materials.
BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a
Heterocyclic compounds and their uses
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BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a variety of cellular processes, e.g., malignant transformation, growth factor signaling, inflammation, and immunity (see Rameh et al., J. Biol Chem, 274:8347-8350 (1999) for a review). The
Heterocyclic compounds and their uses
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BACKGROUND OF THE INVENTION
Cell signaling via 3'-phosphorylated phosphoinositides has been implicated in a variety of cellular processes, e.g., malignant transformation, growth factor signaling, inflammation, and immunity (see Rameh et al., J. Biol Chem, 274:8347-8350 (1999) for a review). The
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