pyridine/inflammation

This invention is concerned with novel 2-substituted oxazolopyridines, their use as medicaments, processes for their preparation, and pharmaceutical compositions comprising the novel compounds. In particular, this invention is concerned with novel 2-substituted oxazolo [4,5-b]pyridines, processes

The present invention relates to novel triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the

BACKGROUND OF THE INVENTION It is an object of this invention to provide novel 6-phenyl-2,3-bis(4-methoxyphenyl)pyridine derivatives. These compounds are active as prostaglandin synthetase inhibitors, analgesic agents, anti-inflammatory agents, anti-arthritic agents, antipyretic agents, and

FIELD OF THE INVENTION This invention relates to biologically active chemical compounds that may be used for immunosuppression or to treat or prevent inflammatory conditions and immune disorders. BACKGROUND OF THE INVENTION Inflammation is a mechanism that protects mammals from invading pathogens.

BACKGROUND OF THE INVENTION The production of a spiro[cyclopentane]-quinolinedione is described in Chem. Pharm. Bull., 17, 1290 (1969). Several additional spiroquinoline diones are disclosed in Bull. Soc. Chim. Fr., 364 (1968). The references do not describe pharmaceutical uses for these

This invention is concerned with novel mercaptoalkylpyridines and derivatives thereof carrying a nuclear unsaturated substituent, methods for their preparation, a method of treating rheumatoid arthritis and related inflammatory diseases with the novel compounds and pharmaceutical compositions

The present invention relates to novel triazolo-pyridines, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP kinases, preferably p38 kinase. They are useful in the

DETAILED DESCRIPTION OF THE INVENTION This invention relates to a method of treating analgesia, inflammation and Type III hypersensitivity disease using 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine. Compound 10 (N-methyl-4-piperidylidene)-10H[1]-benzopyrano[3,2-b]-pyridine has

BACKGROUND OF THE INVENTION The present invention relates to novel triazolo-pyridines, to methods of preparation, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The compounds of the present invention are potent inhibitors of MAP

The present invention relates to 5-oxo-5H-[1]benzopyrano[2,3-b]pyridine derivatives of the formula [I]: ##STR2## wherein R is the same or different and represents hydrogen, alkyl, alkoxy, nitro, hydroxy, acyl, hydroxyalkyl or halogen with the proviso that m is 1,2 or 3, or a tetramethylene

BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates to compounds, compositions and methods useful in treating symptoms of immunological and non-immunological disorders such as allergy, inflammation, shock or other disorders wherein arachidonate metabolites are implicated. 2.

STATE OF THE ART Related pyridines are described in British Patent No. 2,171,097; U.S. Pat. No. 4,299,381 and French Patent No. 2,537.140. OBJECTS OF THE INVENTION It is an object of the invention to provide the novel compounds of formula I and their non-toxic, pharmaceutically acceptable salts and

FIELD OF THE INVENTION This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating inflammation and inflammation-associated disorders, such as arthritis. BACKGROUND OF THE INVENTION Prostaglandins play a major

FIELD OF THE INVENTION This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating inflammation and inflammation-associated disorders, such as arthritis. BACKGROUND OF THE INVENTION Prostaglandins play a major

SUMMARY This application relates to a 1,2,4-Triazolo[1,5a]Pyridine derivative (Compound A) having the following structure: ##STR00001## or a salt thereof, and its use in the treatment of diseases or disorders mediated by JAK2 (Janus Kinase 2). In particular, Compound A is a potent, orally active,