serum androgen levels will be measured in 25 normotensive pregnant women

serum androgen levels will be measured in 25 mild preeclamptic patients

serum androgen levels will be measured in 25 severe preeclamptic patients

Severe Preeclampsia

measurement of serum free and total testosterone

serum androgen levels

Ain Shams University

AinShams University

Serum Androgen Levels as a Marker for the Severity of Preeclampsia

assess if serum androgen levels could be used as a marker for the severity of preclampsia

serum androgen levels as marker for the severity of preeclampsia

Joseph Adel Ibrahiem Johny

Principal Investigator

Patients of the group of nebivolol will take 5 mg of nebivolol daily in the morning. At the end of the first month of treatment, patients classified in the normal BP range based on the results of ABPM (24h SBP/DBP < 130/80 mm Hg) will continue on the same medication scheme. Patients still classified in the stage I hypertensive range the nebivolol group will receive 10 mg of nebivolol daily in the morning. At the end of the 6th month patients classified in the normal BP range based on the results of ABPM will continue on the same medication scheme. Patients classified in the stage I hypertensive range 12,5 mg hydrochlorothiazide will be added. The end of the 12-month period from the beginning of the study indicates the completion of the project.

Patients of the group of telmisartan will take 40 mg of telmisarta daily in the morning. At the end of the first month of treatment, patients classified in the normal BP range based on the results of ABPM (24h SBP/DBP < 130/80 mm Hg) will continue on the same medication scheme. Patients classified in the stage I hypertensive range will receive 80 mg of telmisartan daily in the morning. The same procedure will be repeated at the end of the 6th month from the beginning of the study. Patients classified in the normal BP range will continue on the same medication scheme. For patients still classified in the stage I hypertensive range12,5 mg of hydrochlorothiazide will be added. The end of the 12-month period from the beginning of the study indicates the completion of the project.

Hypertension

Patients of the group of telmisartan will take 40 mg of telmisartan daily in the morning. At the end of the first month of treatment, patients classified in the normal BP range based on the results of ABPM will continue on the same medication scheme. Patients still classified in the stage I hypertensive range will receive 80 mg of telmisartan daily in the morning. At the end of the 6th month from the beginning of the study patients classified in the normal BP range will continue on the same medication scheme. For patients still classified in the stage I hypertensive range12,5 mg of hydrochlorothiazide will be added. The end of the 12-month period from the beginning of the study indicates the completion of the project.

TELMISARTAN

Patients will take 5 mg of nebivolol daily in the morning. At the end of the first month of treatment, patients classified in the normal BP range based on the results of ABPM will continue on the same medication scheme. Patients classified in the stage I hypertensive range the nebivolol group will receive 10 mg of nebivolol daily in the morning. At the end of the 6th month from the beginning of the study patients classified in the normal BP range based on the results of ABPM will continue on the same medication scheme. For patients classified in the stage I hypertensive range 12,5 mg of hydrochlorothiazide will be added. The end of the 12-month period from the beginning of the study indicates the completion of the project

NEBIVOLOL

Hypertension-ABPM Center 3rd department of Internal Medicine

Comparative Study of the Effects of Telmisartan and Nebivolol

Comparative Study of the Effects of Telmisartan and Nebivolol on 24-h Ambulatory Blood Pressure and Arterial Stiffness in Patients With Arterial Hypertension

Change in 24h BP values in patients with stage I arterial hypertension treated with telmisartan and nebivolol

Change in arterial stiffness in patients with stage I arterial hypertension treated with telmisartan and nebivolol

Vasilios Kotsis

PROF. MEDICINE

Aristotle University Of Thessaloniki

blood pressure remaining above goal (< 140/90 mm Hg for the general population and < 130/80 mm Hg for patients with diabetes or renal disease) despite using optimal doses of 3 antihypertensive agents of different classes(including a diuretic) for half to one year.

blood pressure can reach 130/80 mm Hg or less in half year by use of optimal dose of less than 3 antihypertensive agents of different classes

Age>50 years old
Blood pressure ≤ 120/80 mm Hg( 24-hour blood pressure monitor or home blood pressure measurement at 6-9 am and 5-8pm, twice)
No cardiovascular diseases: coronary artery disease(coronary angiography or CTA), cerebrovascular diseases(history, MRI-Lacunar brain stem), Carotid ultrasound
No peripheral angiopathy (ABI<0.9 or lower extremity vessels Doppler ultrasound)
No major cardiovascular risk factors:
Dyslipidemia
Diabetes
Smoke within one year

whole blood, serum, peripheral white blood cells, urine

Hypertension, Resistant to Conventional Therapy

FuWai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College

Xuanwu Hospital, Capital Medical University

The general hospital of Chinese People's Liberation Army

The First Affiliated Hospital of Fujian Medical University

Nanfang Hospital of southern medical university

Hongxinglong Center Hospital

Henan Provincial People's Hospital

TongJi Hospital, TongJi Medical Colleage, HuaZhong University of Science and Technology

The Third People's Hospital of Xuzhou

The First Bethun Hospital of Jilin University

Affiliated Hospital of Jining Medical University

Qingdao Municipal Hospital

Rizhao Port Hospital

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

First Hospital of Shanxi Medical University

The fourth military medical university

West China Hospital，Sichuan Univer

Tianjin Chest Hospital

The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis

The Prevalence and the Prognosis of Resistant Hypertension Ascertained With Systemic Investigation and Optimal Treatment With Antihypertensive Drugs

hui rutai

Director

Chinese Academy of Medical Sciences, Fuwai Hospital

Huazhong University of Science and Technology

Shanghai Jiao Tong University School of Medicine

Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter

Celcius Thermacool Catheter or Chilli II Cooled Ablation Catheter based on physician preference: Saline-Irrigated Radiofrequency Ablation Catheter placed in the renal arteries in a circumferential manner and energy delivered to create 4 burn lesions.

Renal Denervation Group

Sex: Female, Male

The change in systolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline.

Mean Change in Ambulatory Systolic Blood Pressure

The change in diastolic blood pressure as measured by 24 hour ambulatory monitoring at 6 months as compared to from baseline.

Change in Ambulatory Diastolic Blood Pressure

Different time points office systolic blood pressure measurements

Office Systolic BP

Different time points office diastolic blood pressure measurements

Office Diastolic BP

Renal artery blood flow as measured by Renal Aortic Ratio (RAR) = Peak systolic Velocity renal artery / Peak Systolic Velocity Aorta. A >60% stenosis is reported when there is a >3.5:1 Renal to Aortic Ratio.

Renal Aortic Ratio

Renal artery blood flow as measured by Resistive Index. RI = (peak systolic velocity - end diastolic velocity ) / peak systolic velocity. the normal value is ~ 0.60, with 0.70 being around the upper limits of normal

Resistive Index

Dimensions of renal artery, right and left

Renal Artery Dimensions

A blood urea nitrogen (BUN) test measures the amount of nitrogen in blood that comes from the waste product urea. Urea is made when protein is broken down in the body. Urea is made in the liver and passed out in the urine.

Blood Urea Nitrogen

Creatinine measures the level of the waste product in the body. The amount of creatinine in the blood depends partly on the amount of muscle tissue you have. Men generally have higher creatinine levels than women.Normal levels of creatinine in the blood are approximately 0.6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 milligrams per deciliter in adult females. High levels of creatinine indicates kidney impairment.

Creatinine

The total number of anti-hypertensive medications at baseline, 6 months, and 12 months

Anti-hypertensive Medications

Overall Study

Dr. Vivek Y Reddy

Uncontrolled Hypertension

Saline-Irrigated Radiofrequency Ablation Catheter will be placed in the renal arteries in a circumferential manner and energy will be delivered to create 4 burn lesions.
There are 2 devices that can be used---this is optional, based on physician preference:
Celcius Thermacool Catheter Biosense Webster, Inc Diamond Bar, California
or
Chilli II Cooled Ablation Catheter Boston Scientific Corporation San Jose, California

renal artery obstruction/obesity

Serum Androgen Levels as a Marker for the Severity of Preeclampsia

Comparative Study of the Effects of Telmisartan and Nebivolol

The Diagnosis and Treatment of Resistant Hypertension, the Prevalence and the Prognosis

Impact of Renal SympAthetic DenerVation on Chronic HypErtension

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