Placebo: Placebo will consist of cellulose powder (Microcrystalline cellulose:Blanver) in foil packets.

Fecal Microbial Transplant - Fecal microbiome transplant (FMT): 50grams of FMT from a single, universal donor will be administered in 20-30 capsules taken by mouth.
Cellulose x 6weeks

Soluble corn fiber (PROMITOR®: Tate&Lyle), Resistant Wheat Starch 4 (Fibersym®: MGP Ingredients), Acacia Gum (Pre-Hydrated Gum Arabic: TIC GUMS).

Fecal Microbial Transplant
Soluble corn fiber (PROMITOR®: Tate&Lyle), Resistant Wheat Starch 4 (Fibersym®: MGP Ingredients), Acacia Gum (Pre-Hydrated Gum Arabic: TIC GUMS).

Obesity

Metabolic Syndrome

Fecal microbiome transplant (FMT): 50grams of FMT from a single, universal donor will be administered in 20-30 capsules taken by mouth.

Fecal Microbial Transplant

A combination of soluble corn fiber (PROMITOR®: Tate&Lyle), Resistant Wheat Starch 4 (Fibersym®: MGP Ingredients), and Acacia Gum (Pre-Hydrated Gum Arabic: TIC GUMS) for a total of 6 weeks (men 33g/day; women 27g/day)

Fiber

Placebo will consist of cellulose powder (Microcrystalline cellulose:Blanver) in foil packets.

Cellulose

Royal Alexandra Hospital

University of Alberta Hospital

FMT and Fiber in Patients With Metabolic Syndrome

Fecal Microbial Transplantation and Fiber Supplementation in Subjects With Obesity and Metabolic Syndrome

The homeostasis Model Assessment-Insulin Resistance (HOMA-IR) is a mathematical model to predict the interaction between glucose and insulin dynamics across a range of glucose plasma levels assuming a feedback circuit between the liver and β-cells in the pancreas

Assessment of the current health related quality of life will be accomplished by conducting standardized interviews and by using the validated questionnaires EQ-5D Index. Participants will report perceived health outcomes using this validated survey, and rank overall perceived health from 0 (low)- 100 (high).

Dietary intake will be assessed for each clinic using MyFitnessPal.

. Levels of leptin, ghrelin, adiponectin, TNFα, IL-6, LPS (lipopolysaccharide), LPS-binding protein and zonulin will be determined using currently accepted laboratory techniques.

Stool microbiome will be analyzed for Operational Taxonomic Unit determination.

Changes in Fasting lipid profile between baseline and 6 and 12 weeks

The oral glucose tolerance test (OGTT) is a dynamic test that reflects the efficiency of the body to dispose of glucose after an oral load. It is commonly used in clinical scenarios to diagnose glucose intolerance and diabetes. [33] After overnight fast (> 8 h), blood samples for determination of glucose and insulin concentration will be taken at -5, 0, 30, 60, and 120 min following a standard oral glucose load.

Assessed via the standardized hunger and satiety questionnaire (categorical variables with no analog scale)

Assessed via the standardized gastrointestinal tolerance questionnaire (categorical variables with no analog scale)

All individual participant data will be kept private and not distributed to other researchers outside of our study group. After the study is done, we will keep data stored for 25 years.

University of Alberta

The Weston A. Price Foundation

Placebo fecal microbial transplantation (FMT)

Placebo FMT

combined fiber supplement of resistant starch type 4, acacia gum, and soluble corn fiber

Prebiotic Fiber

Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome.

The primary endpoint is the change in insulin sensitivity between the time of screening and 6 weeks following treatment.

weight and height will be combined to report changes in BMI in kg/m^2 between baseline and 6 and 12 weeks

Changes in waist to hip circumferences between baseline and 6 and 12 weeks

Changes HbA1C between baseline and 6 and 12 weeks

Changes fasting glucose between baseline and 6 and 12 weeks

Changes in oral glucose tolerance between baseline and 6 and 12 weeks

Changes in blood pressure between baseline and 6 and 12 weeks

Changes in EuroQol five dimensions questionnaire scores to arrive at the participants quality of life between baseline and 6 and 12 weeks

The SLIM Hunger and satiety questionnaire scores used to arrive at the participants feelings of hunger and satiety. Changes in reported feelings of Hunger and Satiety between baseline and 6 and 12 weeks

Changes in serum levels of leptin, adiponectin, ghrelin, CRP, TNF-α, IL-6, LPS, and LPS-binding protein between baseline and 6 and 12 weeks

Changes in fecal microbiota composition between baseline and 6 and 12 weeks

Changes in stool short chain fatty acid composition between baseline and 6 and 12 weeks

senegalia/obesity

FMT and Fiber in Patients With Metabolic Syndrome

Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome.

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