Randomly in all subjects one quadrant will be allotted as test site for placing stevia gel in the gingival sulcus having probing depth ≥ 5mm after performing thorough scaling and root planing.

Other quadrant will be allotted as a control site for placing placebo in the gingival sulcus having PD≥ 5mm after performing thorough scaling and root planing.

Periodontitis

Stevia has an anti-plaque effect because of its ability in decreasing the formation of bacterial insoluble polymers.It significantly decreases the production of TNF-R and IL-1a and slightly decreases the production of NO in stimulated cells with LPS and THP-1 showing its anti-inflammatory properties.These characteristics in combination with anti-diabetic properties could results in the effective treatment of periodontal diseases.

stevia rebaudiana bertoni

A placebo without the active drug will be placed in the control sites.

placebo

SVS Institute Of Dental Sciences

Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.

Efficacy of Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetic Patients With Periodontitis-A Split Mouth Randomized Controlled Trial.

GCF samples can be eluted from the strips by placing them in Eppendrof® tubes that contained 500 micro-litre of buffer and will be stored at -80℃ until analysis was done. The levels of GCF Ghrelin will be evaluated by using commercially available ELISA kit.

Probing depth (PD): Distance from the gingival margin to the bottom of gingival sulcus in mm.

Dr R Viswa Chandra

Principal Investigator

SVS Institute of Dental Sciences

one group of subjects receives intervention where as other group of subjects receive placebo.

Both stevia gel and placebo syringes are masked from participants and investigators.

250 ml of water mixed with 1g of citric acid.

Overweight

Obesity

Participants will receive a solution of stevia before being administered a fixed meal (lunch). Glucose and insulin levels, and Visual analogue scale data will be collected.

sugar replacements

School of Health sciences, Liverpool Hope University

Stevia Extract and Glucose Homeostasis

Effect of Stevia Extract on Postprandial Glucose Response and Satiety in Overweight and Obese Adults: A Three-arm Crossover Trial.

Change in glucose levels two hours after the administration of a fixed meal

Change in postprandial insulin levels two hours after the administration of a fixed meal

Changes in AUC for glucose throughout the intervention

Grace Farhat

Liverpool Hope University

Glucose Intolerance

This arm will be required to consume 5 stevia drops twice daily in habitual drinks

stevia

University of Manchester

Physiological Effects of Stevia Consumption in Humans

Physiological Effects of Long-term Consumption of Non-nutritive Sweeteners in Humans: a Pilot 12 Week Randomised Trial

blood glucose levels will be measured at baseline (0) and at 15, 30, 45, 60, 90 and 120 min after the consumption of a 75 g glucose load and iAUC will be calculated

body weight will be measured on visit week 0, visit week 6 and visit week 12

participants will fill out 3 days of diet recalls before coming to all 3 study visits using Intake24

waist circumference will be measured on visit week 0, visit week 6 and visit week 12

Appetite questionnaires (three factor eating questionnaire, sweet food frequency questionnaire, Satiety, hunger, and food cravings - using the Control of Eating Questionnaire ) will be completed on visit week 0 and visit week 12

Fasting blood glucose will be measured on visit week 0 and visit week 12.

75g OGTT 2-h blood glucose will be measured on visit week 0 and visit week 12.

Total MET-minutes per week measured via the International Physical Activity Questionnaire (IPAQ).

Number of steps per day. 3 days before visit week 0, visit week 6 and visit week 12

Blood pressure will be measure on visit week 0, visit week 6 and visit week 12

Changes in gut microbiota will be measured by 16S rRNA gene sequencing. This outcome is optional and will be decided by the investigators based on the findings in the primary outcome.

This outcome is optional and will be decided by the investigators based on the findings in the primary outcome

This outcome is optional and will be decided by the investigators based on the findings in the primary outcome.

Nikoleta Stamataki

PhD student

Lancaster University

2-group parallel 12-week intervention study with control group

Food or beverages containing Aspartame in comparison to Stevia or Sucrose

Food or beverages containing Sucrose in comparison to Aspartame or Stevia

Food or beverages containing Stevia in comparison to Aspartame or Sucrose

Type 2 Diabetes

The morning breakfast after a 12-h fast and consumed a standard 469 kcal breakfast consisting of cereal, milk, toast with butter, and orange juice. Tea and crackers with cream cheese sweetened with stevia Whole Foods 365 Brand, aspartame equal sweetener, or sucrose participants consumed this preload 20 min before their test lunch and dinner meals. The Test lunch meal consisted of sandwiches, potato chips, and cookies, and the test dinner meal was a self-selected buffet-type meal (I.e., Macronutrient Self-Selection Paradigm) Geiselman et al,. 1998)

Aspartame

Sucrose

Stevia

Pennington Biomedical Research Center

Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults

Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults: A Pilot Study

Test whether preloads of tea and crackers with cream cheese sweetened with Stevia lover postprandial insulin levels compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by measuring blood insulin and glucose levels immediately prior to the lunch preload,immediately before lunch test meal, and at thirty minutes, one hour, and two hours after the lunch test meal.

Test whether preloads of tea and crackers with cream cheese sweetened with Stevia have different hedonic ratings compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by examining hunger and satiety ratings after the preload.

Test whether preloads of tea and crackers with cream cheese sweetened with stevia have different satiating effects compared to preloads of tea and crackers with cream cheese sweetened with Sucrose or Aspartame by examining food consumption 20 minutes and after lunch and dinner preloads, as well as total food consumption.

stevia/obesity

Stevia Rebaudiana Bertoni on Levels of GCF Glucose and Bio-markers in Diabetics.

Stevia Extract and Glucose Homeostasis

Physiological Effects of Stevia Consumption in Humans

Effects of Stevia on Satiety and Eating Attitudes in Healthy, Overweight and Obese Adults

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