A0- On day 0,before intervention placebo,
Microcrystalline Cellulose (303.8gm)
Butylated Hydroxy Toluene (0.2mg)
Magnesium Stearate (3mg)
Gelatin Capsule Shell (1mg)
weekly,orally,for 90days

A90- On day 90,after intervention placebo,
Microcrystalline Cellulose (303.8gm)
Butylated Hydroxy Toluene (0.2mg)
Magnesium Stearate (3mg)
Gelatin Capsule Shell (1mg)
weekly,orally,for 90days

B0- On day 0,before intervention cholecalciferol,
Cholecalciferol (40,000IU)
Microcrystalline Cellulose (58.1 gm)
Butylated Hydroxy Toluene ( 0.2mg)
Magnesium Stearate (3mg)
Gelatin Capsule Shell (1mg)
80.000IU/week,orally,for 90 days

B90- On day 90,after intervention cholecalciferol,
Cholecalciferol (40,000IU)
Microcrystalline Cellulose (58.1 gm)
Butylated Hydroxy Toluene ( 0.2mg)
Magnesium Stearate (3mg)
Gelatin Capsule Shell (1mg)
80.000IU/week,orally,for 90 days

Stable COPD Patients

• Cholecalciferol (40,000IU),
,Microcrystalline Cellulose (58.1 gm), Butylated Hydroxy Toluene ( 0.2mg),Magnesium Stearate (3mg),Gelatin Capsule Shell (1mg)

Cholecalciferol

Samia Hassan

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in D3 Deficient COPD Patients

Forced Vital Capacity It is the volume of air that can be expired as forcefully and rapidly as possible after maximal inspiration. In adult male it is about 4.6 liters. The FVC is commonly reduced in obstructive processes such as COPD.Increment of Forced Vital Capacity means improvement in outcome.

Forced Expiratory Volume in 1st second When a person inspires maximally and exhales forcefully, then the volume, which is exhaled in 1st second is known as 'Forced Expiratory volume in 1st second`. It is normally 80% of forced vital capacity .
Significance- This measurement is much more sensitive index of severity of the obstructive disease .In COPD ,FEV1 is reduced ,Increment of FEV1 indicates improvent in outcome

Forced Expiratory Ratio It is the ratio of FEV1 to FVC expressed in percentage. FEV1/FVC ratio = FEV1/FVC×100. It is about 70% or higher.
Forced Expiratory Ratio is less than 70% in COPD patients.Increment of Forced Expiratory Ratio indicates improvement in outcome

Peak Expiratory Flow Rate It is the maximum expiratory rate, beyond which the flow cannot be increased even with greatly increased additional force.
In adult it is about 400-700 Liter/second.

Forced Expiratory Flow in the middle of FVC Forced expiratory flow during the middle half of the FVC. Formerly it was called the maximal mid-expiratory flow (MMEF), expressed in liters/second Normal range in male : 1.5-4.5 Liter/second.Increment of Forced Expiratory Flow in the middle of FVC means improvement in outcome.

Maximum expiratory Flow rate at 25%of the FVC (MEF 75) Maximum expiratory flow rate when 25% of the FVC remains in the lung to be exhaled and is equivalent to the FEF75 where 75% of the FVC has been exhaled. Expressed in liters/second.
This is reduced in COPD. Increment in maximum expiratory flow at 25%of the FVC means improvement in outcome

Maximum expiratory Flow at 50%of the FVC(MEF50) Maximum expiratory flow rate when 50 % of the FVC remains in the lung to be exhaled and is equivalent to the FEF50 where 50% of the FVC has been exhaled. Expressed in liters/second. This is reduced in COPD.
Increment in maximum expiratory flow at 50%of the FVC means improvement in outcome.

Maximum expiratory Flow at 75%of the FVC (MEF25) Maximum expiratory flow rate when 75% of the FVC remains in the lung to be exhaled and is equivalent to the FEF25 where 25% of the FVC has been exhaled. Expressed in liters/second.This is reduced in COPD.Increment in maximum expiratory flow at 75%of the FVC means improvement in outcome

Oxygenation variables Peripheral Capillary Oxygen saturation between 96% to 99% is normal.Peripheral Capillary Oxygen saturation between 96% to 99% means improved outcome

Exercise tolerance variables • Six Minute Walk Distance [6MWD (meter) ] minimum 350m in 6minute at a time(without taking any rest) is standard.The more the distance,the more the better outcome.

Level of Dyspnea : Modified Borg Scale If the dyspnea score decreases,it means better outcome If the dyspnea score increases,it means outcome is worse

Level of fatigue: Modified Borg Scale If the fatigue score decreases,it means better outcome, If the fatigue score increases,it means outcome is worse

Principal investigator

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Two groups of Vitamin D3 deficient stable COPD patients were taken, Group A was given placebo along with standard therapeutic treatment and Group B was given Vitamin D3 along with standard therapeutic treatment

Prospective interventional randomized double blinded study

toluene/obesity

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients

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