urea/diarrhea

BACKGROUND OF THE INVENTION Adenosine is an autocoid produced in many tissues to mediate various functions through four receptor subtypes, A1, A2A, A2B and A3. All four receptors belong to the class of G-protein coupled receptors (GPCRs), which contain seven helical hydrophobic domains that span

BACKGROUND OF THE INVENTION The leukotrienes and their biological activities, especially their role in various disease states, have been extensively studied. Their properties are described in the book Leukotrienes and Lipoxygenases, Ed., J. Rokach, Elsevier, N.Y., 1989. Inhibitors of the

BACKGROUND OF THE INVENTION The leukotrienes and their biological activities, especially their role in various disease states, have been extensively studied. Their properties are described in the book Leukotrienes and Lipoxygenase, Ed., J. Rokach, Elsevier, N.Y., 1989. Inhibitors of the