Working Memory and School Readiness in Preschool-Aged Children With Sickle Cell Disease
키워드
요약
기술
Participants will be recruited through the Pediatric Sickle Cell Clinic at St. Jude. All participants with SCD will be evaluated once with laboratory measures of cognitive and pre-academic skills and parent questionnaires. Medical history will be evaluated for purposes of characterizing the health status and disease severity of patients and determining how medical factors are related to school readiness and working memory in SCD population. The study expects to accrue up to 99 participants with SCD.
Demographically-matched control children will be selected from a database of participants enrolled in an ongoing longitudinal study of neurocognitive development in children born in Shelby County, Tennessee. The control group will be randomly selected from an existing study group and will not be enrolled on the MEMREAD protocol. Control group participants will be excluded if they have any sensory or motor impairment that would preclude valid testing (e.g., blindness, paresis), or if they have received treatment with non-stimulant psychotropic medication. A de-identified data file that includes the following results for up to 168 demographically-matched healthy control participants (approximately 1:2 ratio of SCD to healthy control) will be provided for control comparison purposes:
- Health Evaluation (CV4)
- Stanford binet - Fifth Edition (CV4)
- Bracken Basic Concepts Scale - Third Edition (CV4)
- The Behavior Rating Inventory of Executive Function - Preschool Version (BRIEF-P) (CV4)
- The Scales of Independent Behavior - Revised, Early Development Form (SIB-R) (CV4)
- Demographics (CV4)
- Additional Covariates (if any) including gestational age at birth, developmental delays, major medical illnesses, surgery history, neurological event history, pre-kindergarten attendance, and daycare attendance
날짜
| 마지막 확인: | 08/31/2018 |
| 처음 제출: | 08/21/2014 |
| 제출 된 예상 등록: | 08/25/2014 |
| 처음 게시 됨: | 08/27/2014 |
| 제출 된 마지막 업데이트: | 09/10/2018 |
| 마지막 업데이트 게시: | 09/11/2018 |
| 실제 연구 시작 날짜: | 09/07/2014 |
| 예상 기본 완료 날짜: | 08/19/2018 |
| 예상 연구 완료 날짜: | 08/19/2018 |
상태 또는 질병
개입 / 치료
Other: Sickle Cell Disease
Other: Sickle Cell Disease
단계
팔 그룹
| 팔 | 개입 / 치료 |
|---|---|
| Sickle Cell Disease All participants who meet eligibility requirements and consent to the study will complete evaluation of cognitive and pre-academic skills, and parent questionnaires. | Other: Sickle Cell Disease Participants will complete testing to evaluate fluid reasoning, knowledge, quantitative reasoning, visual-spatial processing, verbal and non-verbal working memory, and knowledge of pre-academic skills (such as colors, letters, numbers, counting, sizes, comparisons, and shapes). |
자격 기준
| 공부할 수있는 연령 | 48 Months 에 48 Months |
| 공부할 수있는 성별 | All |
| 샘플링 방법 | Non-Probability Sample |
| 건강한 자원 봉사자를 받아들입니다 | 예 |
| 기준 | Inclusion Criteria: - Patient at St. Jude Children's Research Hospital (SJCRH) with a primary diagnosis of sickle cell disease - 48-68 months of age at time of enrollment - English as primary language Exclusion Criteria: - Sensory or motor impairment that would preclude valid testing (e.g., blindness, paresis) - Treatment with non-stimulant psychotropic medication - Enrollment in kindergarten at time of assessment |
결과
1 차 결과 측정
1. Mean difference in working memory between SCD participants and control group [Once, at enrollment]
2. Mean difference in school readiness between SCD group and control group [Once, at enrollment]
3. Association between working memory and school readiness skills compared between SCD group and control group [Once, at enrollment]
2 차 결과 측정
1. Effect of family/environmental factors and disease severity on measures of working memory [Once, within 6 months of enrollment]
2. Effect of family/environmental factors and disease severity on school readiness [Once, within 6 months of enrollment]
