Bioorganic and Medicinal Chemistry Letters 2014-Sep
A concise diastereoselective approach to enantioenriched substituted piperidines and their in vitro cytotoxicity evaluation.
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요약
A library of diversely stereo-oriented, highly substituted 2,6-cis piperidine derivatives were synthesized, and evaluated for their anticancer activity in cancer cells that included A549 (lung cancer, CCL-185), MCF7 (breast cancer (HTB-22), DU145 (prostate cancer (HTB-81), and HeLa (cervical cancer, CCL-2). One stereo-variant emerged as a promising candidate for further design based structure-activity studies.
