ISOLATION OF FLAVONOID EXTRACT FROM GEORGIAN CITRUS SINENSIS PEEL AND ITS ANTIOXIDATIVE PROPERTIES.

A method for isolation of polyphenol extract with significant amounts of flavonoid compounds (GOF) from precocious Georgian Citrus sinensis peels (Citrus sinensis (L.) Osbeck ,,Seike Navel", form N26) was established by multistage process based on producing water-associated fraction (WAF). Recent study describes the impact of GOF on altered cellular metabolism patterns of cardiac muscle cells and changes in blood induced by psycho-emotional stress. Markedly, GOF-treated animals show positive changes in certain antioxidant enzymes (SOD, catalase) activity and normalization of lipid peroxidation, whereas the concentration of Ca2+ and nitric oxide are approximated to the control value. Similar impacts were also observed in comparison with nobiletin, mainly found in citrus peels. It is notable that in terms of certain parameters, implication of GOF shows more effectiveness than nobiletin.