Impact of Weight Reduction on Adiponectin and TNF-α Levels in the Gingival Crevicular Fluids of Obese Patients with and without Periodontal Disease.

The aim of the current study was to assess the impact of weight loss on the gingival crevicular fluids (GCF) levels of adiponectin and TNF-α in obese patients with periodontal disease.Sixty obese subjects were recruited into the study and were divided into three groups of 20 each. Group 1-periodontally healthy obese patients, group 2-obese patients with gingivitis, group 3-obese patients with periodontitis. The GCF levels of adiponectin and tumor necrosis factor α (TNF-α) were evaluated using ELISA, and the same was correlated with the probing pocket depth (PPD) and clinical attachment loss (CAL) at baseline and after attainment of ≥10% weight reduction.Reductions in body weight resulted in elevated adiponectin and reduced TNF-α levels in the GCF. Adiponectin levels showed significant positive correlations and TNF-α negative correlation with improved periodontal parameters.Weight reduction has an impact on obesity-related inflammatory changes on periodontal disease.Obesity can be a potential risk factor for periodontitis, weight reduction measures can considerably reduce the inflammatory burden on the periodontium.