Journal of Ethnopharmacology 1998-Mar
Piscicidal properties of piperovatine from Piper piscatorum (Piperaceae).
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Extraction of the roots of the Amazonian medicinal plant, Piper piscatorum Trelease and Yuncker, with MeOH and subsequent bioassay guided fractionation using the guppy, Girardina guppii yielded the active amide, N-isobutyl-6-(p-methoxyphenyl) 2E, 4E-hexadieneamide (piperovatine) and a second inactive amide, N-isobutyl-(E)-7-(3,4-methylenedioxyphenyl)hept-2-enamide (pipercallosidine). The former displayed an LC50 of 115 ng/ml in toxicity tests and proved to be the constituent responsible for the dual ethnobotanical uses of this plant: that of fish stupefacient (barbasco) and oral local anesthetic.