Effect of Vigna angularis on High-Fat Diet-Induced Memory and Cognitive Impairments

High-fat diet (HFD)-induced obesity is related to cognitive and memory dysfunction. Much attention was focused on functional foods as a therapeutic strategy to treat cognitive decline by obesity. In the present study, we confirmed the protective effect of Vigna angularis (VA) on cognitive and memory impairment in an obese mouse model. For 16 weeks, mice were fed HFD and VA extract was administered during 4 weeks at 100 and 200 mg/kg. The cognitive abilities of HFD-induced mice were evaluated using behavioral tests. Compared with the control group, VA groups were improved spatial and recognition ability. In T-maze and novel object recognition tests, VA 100 and VA 200 groups showed increased ratios of exploration of a novel object/route compared to a familiar object/route. Moreover, VA 100 and VA 200 groups reached the platform faster than the control group in a Morris water maze test. Therefore, VA extract may protect against HFD-induced cognitive impairment and memory dysfunction. (PNU-IACUC; approval no. PNU-2019-2166).

Keywords: C57BL/6J; adzuki bean; cognitive decline; obesity.