amyloid/atrophy

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페이지 1 ...에서 37 결과

Alkyl, alkenyl and alkynyl chrysamine G derivatives for inhibition of cell degeneration and toxicity associated with amyloid deposition

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The present invention was made utilizing funds from the National Institute of Ageing, grant numbers AG-05443, AG-05133 and AG-08974. This application is a continuation-in-part of U.S. patent application Ser. No. 08/640,704, now abandoned, and also a continuation-in-part of International Patent

Apparatus and method for detecting amyloid in a retina in a diagnosis, advancement, and prognosing of alzheimer's disease, traumatic brain injury, macular degeneration and a plurality of neurodegenerative dissorders, and ocular diseases

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TECHNICAL FIELD & BACKGROUND Imaging of amyloid-beta plaques (including amyloid, amyloid-beta peptides) and other pathology and anatomical features in the retina or brain is often unobtainable without the use of specialized contrast agents, or autofluorescence techniques. While drusen and

Apparatus to detect amyloid in a patient user's retina in a diagnosis, advancement and prognosis of alzheimer's disease, traumatic brain injury, macular degeneration and a plurality of neurodegenerative disorders and ocular diseases

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TECHNICAL FIELD & BACKGROUND Imaging of amyloid-beta plaques including amyloid, amyloid-beta peptides and other pathology and anatomical features in a patient user's retina or a patient user's brain is often unobtainable without the utilization of specialized contrast agents or autofluorescence

Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits

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BACKGROUND OF THE INVENTION The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. More specifically, the present invention relates to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of

Compound for the antemortem diagnosis of Alzheimer's Disease and in vivo imaging and prevention of amyloid deposition

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Humanized anti-beta-amyloid antibodies

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FIELD OF THE INVENTION The present invention relates to antigen binding proteins, including antibodies, that bind .beta.-amyloid peptide and in particular human .beta.-amyloid peptide. The present invention also concerns methods of treating diseases or disorders characterised by elevated

Methods for treatment of beta-amyloid protein-induced ocular disease

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BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to the use of natural product compounds isolated from plants, and synthetic chemical analogues thereof, for the prevention and treatment of beta-Amyloid protein-induced disease. Specifically, the invention relates to

Antigen binding proteins

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This application is a 371 of International Application No. PCT/EP2008/062652, filed Sep. 23, 2008, which claims the priority of GB Application No. 0718737.0, filed Sep. 25, 2007, which are incorporated herein in their entirety. FIELD OF THE INVENTION The present invention relates to methods of

Compounds for inhibiting protein aggregation, and methods for making and using them

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TECHNICAL FIELD This invention generally relates to protein chemistry, cell biology, neuroscience and medicine. The invention provides compositions comprising protein aggregation inhibitors, and pharmaceutical compositions comprising them, and methods for making and using them, including methods for

Compounds for reversing and inhibiting protein aggregation, and methods for making and using them

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TECHNICAL FIELD This invention generally relates to protein chemistry, cell biology, neuroscience and medicine. The invention provides compositions for increasing the clearance of protein aggregates such as amyloid beta protein (A.beta.) aggregates, and pharmaceutical compositions comprising them,

Mono-fluoro beta-secretase inhibitors

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FIELD OF THE INVENTION The present invention relates to novel compounds and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as medicaments for treatment and/or prevention of various diseases. In particular the invention relates to

Compounds and their use as BACE inhibitors

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The present invention relates to compounds and therapeutically acceptable salts thereof, their pharmaceutical compositions, processes for making them and their use as medicaments for treatment and/or prevention of various diseases. In particular the invention relates to compounds, which are

Compounds and their use as BACE inhibitors

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Substituted isoindoles for the treatment and/or prevention of A.beta.- related pathologies

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TECHNICAL FIELD OF THE INVENTION The present invention relates to novel compounds and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of A.beta.-related pathologies such as Downs syndrome, .beta.-amyloid

Compounds and their use as BACE inhibitors

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