Pediatric epilepsy patients who are followed at Children's Hospital Colorado with medically refractory epilepsy, and whom the family has decided to treat with medical cannabis.

Epilepsy, Unspecified, Refractory (Medically)

Pediatric patients with medically refractory epilepsy and treated with medicinal cannabis.

Medical Cannabis

More information about medical marijuana research at childrens hospital colorado

Children's Hospital Colorado

The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

Prolonged EEG recordings lasting 24-48 hours (whichever is clinically indicated) will be performed in either the home setting as an ambulatory EEG or in the hospital in the Epilepsy Monitoring Unit. This decision will be made on a clinical basis. This will allow for objective quantification of seizures in children with frequent seizures that occur on a daily basis and background EEG changes for other children. Two EEGs will be done: one at baseline, and one at the end of the study.

Each subject will maintain a seizure diary. Rescue drug use and VNS (Vagus Nerve Stimulation) activations will be tracked as an adjunct to all current anti-seizure medications. Frequency of status epilepticus will be tracked as well as hospital visits for seizures or adverse events from MCBD. Clinical evaluations will be taken every 2 months throughout the duration of the study. Subjects will be monitored every 2 weeks by telephone and/or email.

Side effects will be evaluated using PESQ (Pediatric epilepsy Side Effects Questionnaire). This questionnaire will be administered 4 weeks, 8 weeks, and 12 weeks after baseline.

University of Colorado, Denver

Colorado Department of Public Health and Environment

Bipolar Affective Disorder

Randomized crossover study of 2 weeks of active study medication (maximum daily dosage of 60 mg) vs. 2 weeks of matching placebo.

anticonvulsants/cannabis

The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

Cannabinoids in Bipolar Affective Disorder

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