BACKGROUND
Buame [17β-(butylamino)-1,3,5(10)-estratrien-3-ol] possesses anticoagulant and antiplatelet activities that are potentially antithrombotic. Since its estrogenicity is unknown, it was evaluated by established methods.
METHODS
Buame (10, 100, 500, and 1,000 μg/kg), 17β-estradiol (E(2)) (100