digitalis/항우울제

The most important cardiovascular interactions between cardioactive drugs and monoamino-oxidase inhibitors or tricyclic antidepressants are reviewed. Post-ganglion blocking agents (e.g., guanethidine), clonidine, reserpine, and alpha-methyl-dopa should not be used in patients needing antide-present

The problem of drug-induced or drug-aggravated cardiac arrhythmias has been recognized for many years. Digitalis glycosides and class I, II, III, or IV antiarrhythmic drugs can cause severe sinus node dysfunction or atrioventricular block. Digitalis can cause a variety of supraventricular

This retrospective study concerns the fatal cases of human poisoning which were collected by computer in the french Poison Control Centers. It involves 865 toxic deaths mainly suicides. The most frequent toxic substances which accounted for lethal cases were in order of importance : psychotropic and

OBJECTIVE An increased number of drugs used by patients enhances the risk of potentially hazardous drug interactions. So far, no representative data are available about how common this problem is in German general practices. METHODS We performed a retrospective analysis using a prescription database

Alcohol interacts with a suprising number of commonly used drugs: antibiotics, anticoagulants, antihistamines, digitalis, monoamine oxidase inhibitors, nitroglycerine, diuretics, heavy metals, insulin, iron, puromycin C, and many others. It also interacts specifically with sedatives, opiates,

Drugs are a very common cause of gynecomastia and should always be entertained as the possible causal agent of such a condition. This drug side-effect is due to an impaired balance in the serum estrogen/serum androgen ratio, whatever the mechanism, or a rise in prolactin level. Sex hormones,

Information contained in the package inserts of drugs chosen as potential causes of blood dyscrasia, renal toxicity, hepatotoxicity, and cardiac toxicity has been studied. Chloramphenicol and pyrazolones were chosen as representatives of drugs that could produce blood dyscrasia, aminoglycosides and

23.3 per cent out of 180 old patients (age above 60 years, 71 y in the mean) suffering from chronic cerebral disorders (3 large groups of disease) developed pharmacotoxic psychoses. This relative high percentage can be explained by psychotoxic side effects of the modern antiparkinson-therapy. The

The relation between breast cancer and selected nonestrogenic drugs was evaluated in the Group Health Cooperative of Puget Sound, Seattle, Washington, a prepaid health care organization with computerized information on diagnoses and outpatient drug use. No important positive associations with breast

Drug-induced arrhythmias are commonly described as proarrhythmia, arrhythmogenesis or aggravation of arrhythmias. A variety of drugs including cardiotonic drugs (antiarrhythmics, digitalis, cathecholamines), psychiatric drugs(phenothiazines, antidepressants), and macrolide antibiotics would worsen

Arrhythmias could be induced or aggravated by a variety of drugs which include cardiotonic drugs (digitalis, catecholamines, antiarrhythmics), psychiatric drugs (phenothiazines, antidepressants), and potassium losing diuretics. Among these, drugs which would lengthen QT interval and thereby

Drug-induced delirium is often seen in clinical practice. Most knowledge about delirium-inducing drugs comes from reports on side effects, and few systematic studies have been done in the field. Delirium is strongly associated with anticholinergic activity; drugs of different classes, including

Immunotherapy of drug intoxications is based on intravenous administration of antibodies or antibody Fab fragments specific to a drug. Mechanism of action involves toxin complexation in the antibody distribution space resulting in a gradient efflux of the toxin from its binding site by dissociation

Immunotoxicotherapy has been used against animal venoms for almost a century. The last several years have brought major innovations in its safety and efficacy, the processes of fragmentation permitting a greater volume of distribution, diminished risk of sensitization and renal elimination. This

Drug-induced cognitive impairment is a common cause of delirium and is frequently a confounding factor in dementia. Predisposing conditions for delirium include age, brain disease and addiction to alcohol and/or drugs. The elderly are at particular risk because of multiple diseases, multiple drug