Stage I/II NSCLC patients receiving standard stereotactic body radiation therapy and Stage III patients receiving Standard platinum-based chemoradiotherapy will receive PET/MRI, DCE-CT, ECG/EKG, and bloodwork before and six weeks post treatment.

Non-small Cell Lung Cancer

Radiation Toxicity

Stage III patients: Standard platinum-based chemotherapy, total radiation dose 60 Gy in 30 fractions. Stage I/II patients: Standard radiotherapy, total radiation dose of 54 Gy in 3 fractions (peripheral), 55 Gy in 5 fractions (near chest wall), or 60 Gy in 8 fractions (central).

Standard platinum-based chemoradiotherapy

Lawson Health Research Institute

Detecting Radiation-Induced Cardiac Toxicity After Non-Small Cell Lung Cancer Radiotherapy

Identification of Acute Radiation-induced Cardiac Toxicity After Non-small Cell Lung Cancer Radiotherapy With Advanced Multi-modality Imaging (RICT-LUNG)

FDG-PET imaging to detect increase in cardiac inflammation compared to baseline with corresponding blood markers (Erythrocyte Sedimentation Rate (ESR), high sensitivity C-reactive protein, and troponin levels in blood (inflammation)).

DCE-CT imaging to detect changes in acute cardiac perfusion changes compared to baseline.

Contrast-enhanced CT imaging to detect acute changes in LVEF compared to baseline.

Gadolinium Enhanced MR imaging to detect cardiac fibrosis compared to baseline

FDG-PET imaging to detect tumour metabolism changes compared to baseline.

DCE-CT imaging to detect changes in tumour perfusion compared to baseline

4D-CT imaging to detect changes in lung ventilation compared to baseline

DCE-CT imaging to detect changes in lung perfusion compared to baseline

Canadian Institutes of Health Research (CIHR)

These patients will have echocardiography guided fluid management

Fluid management will be guided by monitoring of central venous pressure and urine output.

Peritoneal Neoplasms

Echocardiography Guided Fluid Management

Echocardiography will be utilized during the procedure to guide fluid management.

Echocardiogram

The Nebraska Medical Center

Comparison of Traditional and Echocardiography Guided Fluid Management During Cytoreductive Surgery With HIPEC

Comparison of Traditional (Central Venous Pressure (CVP) and Urine Output Guided) Versus Echocardiography Guided Fluid Management in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

The amount of fluid administered during the intraoperative period will be monitored and recorded. The outcome measure of interest is the difference between fluid given in the standard group vs the echo guided fluid management group.

Amy Duhachek-Stapelman, MD

Principal Investigator

University of Nebraska

Esophagectomy via Right Side Thoracotomy Plus Midline Laparotomy Approach

Esophageal Cancer

Postoperative Complications

Diaphragm

Pulmonary Function

Ivor-Lewis Esophagectomy

Esophagectomy through Left Side Thoracotomy

Sweet Esophagectomy

Thoracic Surgery Department, West China Hospital of Sichuan University

Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches

A Phase Ⅲ Study of Respiratory Complications Associated With Esophagectomy Through Either Ivor-Lewis or Sweet Approach for the Treatment of Middle or Lower Third Intrathoracic Esophageal Carcinoma

esophageal neoplasms/edema

Detecting Radiation-Induced Cardiac Toxicity After Non-Small Cell Lung Cancer Radiotherapy

Comparison of Traditional and Echocardiography Guided Fluid Management During Cytoreductive Surgery With HIPEC

Esophagectomy Associated Respiratory Complications: Ivor-Lewis Versus Sweet Approaches

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