The invention provides a medical device having a thermister for temperature measurement, irrigation/aspiration ports for fluid exchange and application of therapeutic modalities, a pressure manometer for pressure measurement, and an external system for control of temperature, pressure, and flow rate. When applied to the central nervous system (CNS), this device can be used in hypothermia or hyperthermia applications, the exchange of cerebral spinal fluid (CSF), the application of treatment modalities, and the insertion of a ventriculostomy or ventriculostomy-like unit. When applied to spinal cord applications, this device can provide temperature control and a method for application of treatment modalities by using a venting device placed in the space surrounding the spinal cord, a device with similar instrumentation to measure temperature and pressure. A device for ultrasound localization of the CNS device is described. A device for a fiber optic endoscope for visualization and localization is also described. Method of using the devices in treating patients suffering from cardiac arrest, circulatory arrest, exsanguination, head or neck trauma, strokes, tumors and other intracranial diseases are disclosed. In the case of hypothermia treatment of the brain, rapid cooling using principles of convection and conduction will be applied to the lateral ventricle and subarachnoid and/or subdural space simultaneously where the neurons are located in close proximity.

Medical device and method for temperature control and treatment of the brain and spinal cord

The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The present invention provides for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of mucus to the dry fluid yields evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. Therefore, therapeutic hypothermia may be achieved for neuroprotection of various organs after ischemic insult, like the brain after cardiac arrest. Similarly, excess fluid removal is achievable for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

The Johns Hopkins University

THE JOHNS HOPKINS UNIVERSITY

Method and device for non-invasive anatomical and systemic cooling and neuroprotection

A portable cooler is provided for heat exchange catheters that is powered by one or more batteries. The cooler can include Rankine cycle compressor components or thermoelectric cooler (TEC) components. The cooler can be carried in an ambulance and used to support coolant to an indwelling heat exchange catheter that is placed in the patient's venous system to prevent fever and/or induce therapeutic moderate hypothermia in, e.g., stroke victims, heart attack victims, and cardiac arrest victims.

heart arrest/fever

Medical device and method for temperature control and treatment of the brain and spinal cord

Method and device for non-invasive anatomical and systemic cooling and neuroprotection

Portable cooler for heat exchange catheter

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