huntington disease/비만증

FIELD OF THE INVENTION Provided herein are certain aryl- and heteroaryl-nitrogen-heterocyclic compounds that are PDE10 inhibitors, pharmaceutical compositions containing such compounds, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases

FIELD OF INVENTION The present invention relates to novel 3-(indol-3-yl)-pyridine derivatives, including pharmaceutically acceptable enantiomers, salts and solvates thereof. Compounds of the invention are inhibitors of TDO2 (tryptophan 2,3-dioxygenase) and are useful as therapeutic compounds,

BACKGROUND 1. Technical Field of Invention The present invention embodiments relate to novel 4-(indol-3-yl)-pyrazole derivatives, including pharmaceutically acceptable enantiomers, salts and solvates thereof. Compounds of certain embodiments of the invention are inhibitors of TDO2 (tryptophan

BACKGROUND OF THE INVENTION Obesity, defined as excess adiposity for a given body size, results from a chronic imbalance between energy intake and energy expenditure. Body mass index (BMI, kg/m.sup.2) is an accepted clinical estimate of being overweight (BMI 25 to 30) and of obesity (BMI>30). A

FIELD OF INVENTION The present invention relates to novel 3-(indol-3-yl)-pyridine derivatives, including pharmaceutically acceptable enantiomers, salts and solvates thereof. Compounds of the invention are inhibitors of TDO2 (tryptophan 2,3-dioxygenase) and are useful as therapeutic compounds,

FIELD OF THE INVENTION This invention relates to carbocyclic compounds that inhibit the activity of glycogen synthase kinase 3 (GSK3), to pharmaceutical compositions containing the compounds and to the use of the compounds and compositions, alone or in combination with other pharmaceutically active

Throughout this application, various publications are referenced in parentheses the first author's last name and year of publication. Citations for these references may be found at the end of the specification immediately preceding the claims. The disclosures of these publications in their

FIELD OF THE INVENTION The invention relates to novel substituted 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines, serotonin 5-HT.sub.6 receptor antagonists, active ingredients and pharmaceutical compositions, comprising the said compounds as active ingredients, method for treatment and prophylaxis of

TECHNICAL FIELD OF THE INVENTION The invention relates to the area of G-protein coupled receptors. More particularly, it relates to the area of human neuropeptide Y-like G protein-coupled receptor and its regulation. BACKGROUND OF THE INVENTION G-Protein Coupled Receptors Many medically significant

FIELD OF THE INVENTION This invention relates to methods for discovering agonists and antagonists of the interaction between UDP-sugars (e.g.,UDP-glucose, UDP-galactose, UDP-glucuronic acid, and UDP-N-acetyl glucosamine) and their cellular receptor, human KIAA0001 receptor. The invention also

FIELD OF INVENTION This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to G-protein coupled

FIELD OF INVENTION This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More articularly, the polynucleotides and polypeptides of the present invention relate to G-protein coupled

FIELD OF INVENTION This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to G-protein coupled

FIELD OF THE INVENTION This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in therapy and in identifying compounds that may be agonists or antagonists that are potentially useful in therapy, and to production of such polypeptides and

FIELD OF THE INVENTION This invention overall relates to the field of human genetics. More particularly, this invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to the use of polynucleotides in gene therapy, and to production of such polypeptides and