hydrolase/hypoxia

OBJECTIVE Shoot elongation of arrowhead tubers (Sagittaria pygmaea Miq.) is stimulated by anoxia, ethylene and CO2. The aim of this study was to characterize anoxic elongation by comparison with elongation stimulated by ethylene and CO2. METHODS The effects of the inhibitors aminoethoxyvinylglycine

Calpain proteases contribute to hepatocyte necrosis during anoxia. Our aim was to ascertain the mechanism causing calpain activation during anoxia. In rat hepatocytes, a twofold increase in calpain activity occurred despite the lack of an increase in cytosolic Ca2+ concentration ([Ca2+]i). The

In rats exposed to hypoxia (breathing 11% O2-N2 for 15 min), activity of neutral peptide hydrolases in lungs and serum was measured before and after altitude chamber training. When exposed to normal air breathing, activity of lung neutral peptide hydrolases was markedly higher in Group 1 rats, i.e.

The citric cycle dehydrogenases and neutral peptide hydrolases (NPH) activity was determined in the myocardium and blood serum of Wistar rats under acute and prolonged hypoxic hypoxia. It was shown that the NPH activity and the activity of the most oxidative enzymes change in the same direction

The effect of acute oxygen deficiency on the rat brain peptide-hydrolases (EC 3.4) activity was studied under conditions of acute hypoxic hypoxia (the pressure in altitude chamber 240 mm Hg) with concomitant hypothermia (--5.8 degree C) and without it. The activity of neutral peptide hydrolases

Activity of neutral peptide-hydrolases in blood plasma and content of catecholamines in the tissues of rats under conditions of their stay in mountains at different height have been studied in dynamics. Unidirectional phase changes in activity of proteolytic enzymes of blood plasma and content of

OBJECTIVE Tissue hypoxia induces a variety of functional changes including enhanced transcriptional activity associated with high transmethylation activity (e.g. mRNA cap methylation) in the nucleus. It is well known that the kidney responds to hypoxia with enhanced transcription of erythropoietin

OBJECTIVE The C-terminal domain of the soluble epoxide hydrolase (sEH) metabolizes epoxyeicosatrienoic acids (EETs) to their less active diols, while the N-terminal domain demonstrates lipid phosphatase activity. As EETs are potent vasoconstrictors in the pulmonary circulation, we assessed the

Athletes were taken to an altitude of 2100 m and allowed to get adapted to the highland environment for a month. Then blood serum neutral peptide-hydrolases were measured at rest and after exercise. Also, metabolic and respiratory parameters were investigated. In response to identical workloads some

1. Five-day-old anaesthetized rats subjected to slow, prolonged asphyxia (50-55 min) were either allowed to die or resuscitated when at the point of death. Activities of various cerebral acid hydrolases known to be associated with lysosomes were determined in these animals and in littermate

The study addressed the hypothesis that soluble epoxide hydrolase (sEH) inhibition, which increases cardiovascular protective epoxyeicosatrienoic acids (EETs), exerts beneficial effects in an established chronic heart failure (CHF) model. In CHF rats, left ventricular (LV) function, perfusion and

N-acylethanolamines (NAEs) are endogenous lipid ligands for several receptors including cannabinoid receptors and peroxisome proliferator-activated receptor-alpha (PPAR-α), which regulate numerous physiological functions. Fatty acid amide hydrolase (FAAH) is largely responsible for the degradation

The present investigation was undertaken to determine the effect of various ions on the characteristics of S-adenosylhomocysteine (SAH) hydrolase from bovine kidney. The binding sites of [3H]-adenosine to purified SAH hydrolase were not influenced by phosphate, magnesium, potassium, sodium, chloride

Ubiquitin (Ub) is a small 76-residue protein, involved in intracellular protein degradation through a specific ATP-dependent system, which uses Ub as a tag to label proteins committed to be hydrolyzed by a specific 26 S protease. PGP-9.5 is another important component of the Ub system, i.e. a