migraine disorders/비만증

FIELD OF THE INVENTION This invention is related to 3-aminopyrrolidone derivatives and analogues of the following general formula I ##STR00001## and pharmaceutically acceptable salts thereof, that are active as sodium and/or calcium channel modulators and therefore useful in preventing, alleviating

TECHNICAL FIELD The present invention relates to a novel 1,3-dialkylurea derivative which has inhibitory effects on endopeptidase 24.11 and is useful as a therapeutic agent for cardiovascular diseases such as heart failure and hypertension, renal diseases such as renal failure, gastroenteric

FIELD OF THE INVENTION The present invention is directed to alicyclic imidazoles which interact with the histamine H.sub.3 receptor as agonists, antagonists or inverse agonists; pharmaceutically active compositions containing such compounds; and the use of such compounds in formulations for the

BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other

FIELD OF THE INVENTION The present invention is directed to a novel crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment anxiety and related

TECHNICAL FIELD OF THE INVENTION The present invention belongs to the field of pharmaceutical industry and refers to novel ergoline derivatives of optionally substituted 2-propinylamine, which are useful in the pharmaceutical industry as active substances for the manufacture of medicaments used in

BACKGROUND OF THE INVENTION The present invention relates to derivatives of 2,3,4,4a-tetrahydro-1H-pyrazino[1,2,-a]quinoxalin-5(6H)ones which are serotonin 5-hydroxytryptamine 2.sub.C (5HT.sub.2C) receptor agonists useful for the treatment of disorders such as obsessive-compulsive disorder,

TECHNICAL FIELD The present invention relates generally to a method of modulating substance P by compounds containing calcium sulfate, particularly syngenite, gorgeyite and gypsum, and more specifically, to the synthesis of such compounds as well as their use to treat a variety of conditions

FIELD OF THE INVENTION The present invention is directed to novel substituted sulfamide derivatives, pharmaceutical compositions containing said derivatives and the use of said derivatives form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and

BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other

This is the national stage under 35 U.S.C. .sctn.371 of application no. PCT/US92/08306 filed Oct. 6, 1992. BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to

BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other

BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other

BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of the present invention are useful in treating migraine and other

This application is a 371 of PCT/US93/01667 filed Mar. 3, 1993. BACKGROUND OF THE INVENTION The present invention relates to indole derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use. The active compounds of