Fixed combination of black cohosh EP-40 and Rhodiola rosea EPR-7 206.5 mg orally twice daily; daily dose 413 mg of active ingredients

Black cohosh 500 mg orally twice daily; daily dose 1000 mg of active ingredient

Placebo capsule 600 mg excipients orally twice daily

Black cohosh 6.5 mg orally twice daily; daily dose 13 mg of active ingredient

Menopause

Fixed combination of black cohosh and Rhodiola rosea

Menopause Relief EP-40

Low Dose Black Cohosh

High Dose Black Cohosh

Placebo

I.Zhordania Institute of Reproductology

Effect of Menopause Relief EP-40 in Women With Menopausal Symptoms

Efficacy of Menopause Relief EP-40 - Fixed Combination of Cimicifuga EP-40 and Rhodiola EPR-7 Extracts in Women With Menopausal Symptoms: A Randomized, Double Blind, Placebo Controlled Study

A modified total Kupperman Index (KMI) score and its sub-items will be used. It is a 10-item questionnaire of single symptoms with scores ranging from 0 to 3 (none, mild, moderate and severe). Total KMI is defined as the sum of sub-item scores multiplied by any weighting factors. The maximum value of the total KMI is 48. The primary outcome will be the difference in the changes from baseline to the end of therapy (week 12), between verum groups and placebo, assessed by the total KMI and stratified by individual baseline scores in an intention-to-treat (ITT) analysis (patients treated with study medication and with at least one efficacy assessment after baseline).

The MRS is a patient reported assessment of 11 symptoms of menopause on a scale of 0 (none) to 4 (very severe). The MRS groups symptoms into three subscales: psychological, somatic, and urogenital. A composite score is calculated by adding the items in each dimension (subscale). The total score is the sum of the three dimensional scores. The primary outcome will be the difference in the changes from baseline to the end of therapy (week 12), between both verum groups and placebo, assessed by the MRS and stratified by individual baseline scores in an intention-to-treat (ITT) analysis (patients treated with study medication and with at least one efficacy assessment after baseline).

EuroPharma, Inc.

Rhodiola rosea 200mg up to four times a day for 28 days

Placebo pill manufactured to mimic Rhodiola rosea 200mg, up to four times a day for 28 days

Attention Deficit/Hyperactivity Disorder

Rhodiola rosea 200mg pill up to four times a day

Rhodiola

Hospital de Clínicas de Porto Alegre

Rhodiola Rosea in Adults With Attention Deficit/Hyperactivity Disorder

Hospital de Clinicas de Porto Alegre

Attention Deficit Hyperactivity Disorder

innocuous pill manufactured to mimic Rhodiola

Effects of 800mg of Rhodiola Rosea in Attention in Adults With Attention-Deficit/Hyperactivity Disorder

Change from baseline attention 4 hours after a single dose of Rhodiola 800mg or placebo

Rhodiola crenulata for the first treatment period and placebo for the second treatment period, with a washout period of 4 months. Overall study population were 120 subjects, who were randomised and allocated into 2 sequences.

Placebo for the first treatment period and Rhodiola crenulata for the second treatment period, with a washout period of 4 months. Overall study population were 120 subjects, who were randomised and allocated into 2 sequences.

Acute Mountain Sickness

Environmental Illness

Rhodiola crenulata:capsules, 800 mg daily for 7 days before ascent and 2 days during mountaineering

Rhodiola crenulata

Placebo:capsules, 800 mg daily for 7 days before ascent and 2 days during mountaineering

placebo

International society of mountain medicine

Acute mountain sickness, Kingnet, national web hospital

wilderness medicine, medicine and the spirit of adventure

Dept of Emergency medicine, Chang Gung Memorial Hospital

Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness

Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness.

The LLS rates 5 symptoms (headache, gastrointestinal symptoms such as nausea and vomiting, fatigue and/or weakness, dizziness and/or light-headedness, and difficulty sleeping), with each item graded on a scale from 0 to 3. A score of 3 points or greater constitutes AMS.

Blood oxygen content was measured by pulse oximetry (NPB 40, Nellcor, Pleasanton, CA, USA) within 1-2 hours after ascent to altitude 3100m.

Incidence measured by Lake Louise acute mountain sickness score (LLS) ≥ 5 with headache and one other symptom.

severe headache is determined by cut off between scores of 1 and 2 on the Lake Louise survey (ascending scale of 0-3 for severity)

Chang Gung Memorial Hospital

National Science Council, Taiwan

Fatigue

1 capsule = 182 mg Rhodiola rosea extract standardized to 2.8% total rosavins. Take 2 capsules at start of wakeful period each day. Participants will self-determine need for second dose, of 1 capsule, within 4 hours of the initial dose.

Rhodiola rosea

University of Alberta

Rhodiola Rosea for Mental and Physical Fatigue

A Randomized Trial of Rhodiola Rosea for Mental and Physical Fatigue in Nurses

A vitality subscale of the generic health-related quality of life instrument, RAND-36, will be employed to assess fatigue.
A Visual Analogue Scale for Fatigue (VAS-F) will be concurrently administered to assess fatigue and compare to the RAND-36 fatigue assessment.

The health-related quality of life, RAND-36 will also assess physical functioning, role limitations caused by physical health problems, role limitations caused by emotional problems, social function, emotional well-being,and general health perceptions

Measure Yourself Medical Outcomes Profiles to measure change in items of importance to the participant, as identified by the participant.

Adaptive Capacity Index - 21 item questionnaire to measure a subject's ability to adapt to stressors

rhodiola/fatigue

Effect of Menopause Relief EP-40 in Women With Menopausal Symptoms

Rhodiola Rosea in Adults With Attention Deficit/Hyperactivity Disorder

Effects of 800mg of Rhodiola Rosea in Attention in Adults With Attention-Deficit/Hyperactivity Disorder

Can Rhodiola Crenulata Intake Improve Oxygen Saturation and Decrease the Incidence of Acute Mountain Sickness

Rhodiola Rosea for Mental and Physical Fatigue

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