Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis.

OBJECTIVE

Previous case-control studies suggested the single nucleotide polymorphism of cyclooxygenase-2 (COX-2) gene (G-765C) is associated with coronary artery disease (CAD) and ischemic stroke. However, other studies did not confirm this relationship. The objective was to assess the relationship of COX-2 G-765C and CAD and ischemic stroke, using a meta-analysis.

METHODS

Databases, including PubMed, EMbase, CBM and CNKI, were searched to get the genetic association studies. Data were extracted by two authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.

RESULTS

The meta-analysis included 4930 CAD patients and 17,997 controls, as well as 1628 ischemic stroke patients and 17,653 controls. For CAD, the pooled OR of -765C was 0.80 (95%CI: 0.65-0.98) compared to wild type allele in recessive model, and was 0.99 (95%CI: 0.92-1.06) in dominant model. For ischemic stroke, the pooled OR of -765C was 1.11 (95%CI: 0.88-1.42) in recessive model compared to wild type allele, and was 1.05 (95%CI: 0.93-1.18) in dominant model. No publication bias was found in this meta-analysis.

CONCLUSIONS

The synthesis of available evidence supports that the COX-2 G-765C is protective for CAD. However, it is not associated with ischemic stroke.