Chinese Journal of Oncology 2001-May
[beta-elemene induces apoptosis of K562 leukemia cells].
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OBJECTIVE
To investigate the apoptosis-inducing effect of beta-elemene on K562 leukemia cells.
METHODS
Hoechst 33342 and PI fluorescence staining, DNA fragmentation, electron microscopy, flow cytometry, and immunocytochemistry were used to evaluate the effect of beta-elemene on K562 cells.
RESULTS
beta-elemene heatment induced the formation of apoptotic bodies and DNA ladder. The effect was dose- and time-dependent. The expression of bcl-2 was decreased in beta-elemene treated cells as compared with the untreated control cells.
CONCLUSIONS
beta-elemene exerts its cytotoxic effect on K562 leukemic cells by the induction of apoptosis.
