Phyto-fabricated Cr ₂ O ₃ nanoparticle for multifunctional biomedical applications

Aim: The biosynthesis of chromium oxide nanoparticles (Cr₂O₃ NPs), using Hyphaene thebaica as a bioreductant, for assessment of their potential nanomedicinal applications. Materials & methods: Biosynthesized Cr₂O₃ NPs were characterized by x-ray diffraction, Fourier-transform infrared spectroscopy, energy dispersive x-ray spectroscopy, scanning and transmission electron microscopy, selected area electron diffraction, UV-Vis spectroscopy and ζ-potential measurement. In vitro assays were used to assess the biological properties of Cr₂O₃ NPs. Results: Nanoparticles with size approximately 25-38 nm were obtained with a characteristic Cr-O vibration at 417 cm^-1. A broad spectrum antimicrobial potential and antioxidant nature is reported. Slight inhibition of polio virus and biocompatibility at low doses was observed. Conclusion: We conclude a multifunctional nature of biogenic Cr₂O₃ NPs.

Keywords: Cr2O3 NPs; Hyphaene thebaica; antimicrobial; antioxidant; antiviral; biosynthesis.