Proposal for Initiative of Evidence-based Treatment of COVID-19 Patients with Worsening Hypoxia

The global spread of COVID-19 resulting in severe Acute Respiratory Syndrome was classified by the WHO as pandemic in March 2020. Coronavirus (Covid-19) is an ongoing pandemic of coronavirus disease 2019 (COVID 19) caused by severe acute respiratory syndrome coronavirus 2 (SARS CoV 2). The disease was first identified in December 2019 in Wuhan, China. The World Health Organization declared the outbreak a Public Health Emergency of International Concern on 30 January 2020 and a pandemic on 11 March. As of 16 September 2020, more than 29.6 million cases have been reported in 188 countries and territories, resulting in more than 935,000 deaths 1. The severe and refractory hypoxia resulting from COVID-19 induced respiratory failure is the dominant cause of death. The situation for ICU admitted patients especially requiring mechanical ventilation remains bleak. The purpose of this study is to show how to improve respiratory symptoms in Covid-19 patients and prevent further mortalities. The reported mortality in those patients requiring mechanical ventilation in general at 28 days is 97% 2. This is in accord with our own experience at Hunt Regional ICU. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/).