alpha mannosidase/nutukimas

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Enzymatic glycosidase activities in experimental obesity.

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Glycosidases are lysosomal enzymes that participate in the catabolism of glycoproteins and other glycoconjugates, and in some way may modify their activity in situations in which carbohydrate metabolism could be altered, such as the case of obesity. Using a fluorometric assay, a study was made of

Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.

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OBJECTIVE To investigate the role of the endoplasmic reticulum (ER) chaperone glucose-regulated protein (GRP) 78/BiP in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. METHODS Male Grp78(+/-) mice and their wild-type littermates were subjected to a high-fat diet (HFD) regimen.

The effects of parabiosis on serum and kidney glycosidase activities in spontaneously diabetic mice.

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Spontaneously diabetic non-obese mice of the ICR strain were newly inbred in Shionogi laboratory, Japan. Animals became diabetic suddenly, more frequently and severely in females. Blood glucose levels were 452 +/- 73 mg/100 ml with serum insulin levels of less than 1.0 microU/ml in the fed state.

Diagnostic serum glycosylation profile in patients with intellectual disability as a result of MAN1B1 deficiency.

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Congenital disorders of glycosylation comprise a group of genetic defects with a high frequency of intellectual disability, caused by deficient glycosylation of proteins and lipids. The molecular basis of the majority of the congenital disorders of glycosylation type I subtypes, localized in the

Dietary Green Pea Protects against DSS-Induced Colitis in Mice Challenged with High-Fat Diet.

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Obesity is a risk factor for developing inflammatory bowel disease. Pea is unique with its high content of dietary fiber, polyphenolics, and glycoproteins, all of which are known to be health beneficial. We aimed to investigate the impact of green pea (GP) supplementation on the susceptibility of

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