alpha viniferin/karagana

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A novel role for α-viniferin in suppressing angiogenesis by blocking the VEGFR-2/p70S6K signaling pathway.

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Angiogenesis plays important roles in pathological conditions such as cancer and inflammation as well as normal tissue development and homeostasis. Here, we investigated the effects and molecular mechanisms of α-viniferin, an oligostilbene isolated from Caragana sinica, on human umbilical vein

α-Viniferin Improves Facial Hyperpigmentation via Accelerating Feedback Termination of cAMP/PKA-Signaled Phosphorylation Circuit in Facultative Melanogenesis.

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Rationale: cAMP up-regulates microphthalmia-associated transcription factor subtype M (MITF-M) and tyrosinase (Tyro) in the generation of heavily pigmented melanosomes. Here, we communicate a therapeutic mechanism of hyperpigmented disorder by α-viniferin, an active constituent of Caragana sinica.

(+)-Alpha-viniferin, an anti-inflammatory compound from Caragana chamlagu root.

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The roots of Caragana chamlagu Lamarck (Leguminosae) are used as an anti-neuralgic, anti-rheumatic, anti-arthritic, etc. in the folk medicine of Korea. An ether extract was fractionated with monitoring of the anti-inflammatory activity, and the active principle was elucidated as (+)-alpha-viniferin

(+)-Alpha-viniferin, a stilbene trimer from Caragana chamlague, inhibits acetylcholinesterase.

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In the course of screening natural products for anti-acetylcholinesterase (AChE) activity, we found that a total methanolic extract of the underground parts of Caragana chamlague (Leguminosae) had significant inhibition towards AChE. Bioactivity-guided fractionation of the total methanolic extract

Oligomeric stilbenes from the root of Caragana stenophylla.

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Caragaphenol A (1), a new trimeric stilbene, was isolated from the roots of Caragana stenophylla (Leguminosae) along with three known oligomeric stilbenes: (+)-alpha-viniferin (2), miyabenol C (3) and kobophenol A (4). The stereostructure of 1 was elucidated by one- and two-dimensional (1D- and

Neuraminidase inhibitors from Caragana sinica (Buc'hoz) Rehder roots

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Two new oligostilbenes, caragasinins D (1) and E (2), along with four known compounds, kobophenol A (3), α-viniferin (4), wistin (5), and 5-hydroxy-2-[2-(4-hydroxyphenyl)acetyl]-3-methoxylbenzoic acid (6) were isolated from Caragana sinica roots. These compounds were spectroscopically analyzed for

Antioxidative oligostilbenes from Caragana sinica.

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Two new oligostilbenes, caragasinins A (5) and B (10), and eight known compounds, kobophenol A (1), (+)-α-viniferin (2), (+)-ampelopsin F (3), pallidol (4), (+)-isoampelopsin F (6), miyabenol C (7), carasinaurone (8) and caraphenol B (9) were isolated from the ethylacetate-soluble extract of the

Simultaneous determination of the contents of three stilbene oligomers in Caragana sinica collected in different seasons using an improved HPLC method.

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The objectives of this research were to determine simultaneously the contents of two stilbene tetramers, carasinol B (1) and kobophenol A (2), and one stilbene trimer, (+)-alpha-viniferin (3), in the roots, tubers, and leaves of Caragana sinica in various seasons. A HPLC method has been developed

Caragasinin C: a new oligostilbene from the roots of Caragana sinica.

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A new oligostilbene, caragasinin C (1), and seven known compounds, betulinic acid (2), 4-hydroxybenzaldehyde (3), (‒)-medicarpin (4), wistin (5), (2E,4S)-4-hydroxy-2-nonenoic acid (6), pallidol (7), and (+)-α-viniferin (8), were isolated from the roots of Caragana sinica. The structure of

Determination of hypaphorine and oligomeric stilbenes in the root of Caragana sinica by capillary electrophoresis with electrochemical detection.

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Capillary electrophoresis with electrochemical detection (CE-ED) was employed for the determination of hypaphorine (an alkaloid) and four oligomeric stilbenes (including pallidol, kobophenol A, miyabenol C and (+)-alpha-viniferin) in Radix seu Cortex Caraganae Sinicae, the root of Caragana sinica

Stilbene derivatives as human 5-HT(6) receptor antagonists from the root of Caragana sinica.

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The 5-HT₆ receptor (5-HT₆R) is a member of the class of recently discovered 5-hydroxytryptamine (5-HT) receptors. Due to the lack of selective 5-HT₆R ligands, the cellular signaling mechanisms of the 5-HT₆R are poorly understood. We previously developed a cell-based high-throughput screening (HTS)

Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression.

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BACKGROUND Alzheimer's disease represents one of the main neurological disorders in the aging population. Treatment options so far are only of symptomatic nature and efforts in developing disease modifying drugs by targeting amyloid beta peptide-generating enzymes remain fruitless in the majority of

Identification and determination of oligomeric stilbenes in the roots of Caragana species by capillary electrophoresis.

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A method based on capillary electrophoresis with electrochemical detection (CE-ED) was employed for the determination of one alkaloid (hypaphorine) and the four oligomeric stilbenes, pallidol, kobophenol A, miyabenol C and (+)-alpha-viniferin in the roots of Caragana species. The five analytes could

Naturally occurring protein kinase C inhibitors; II. Isolation of oligomeric stilbenes from Caragana sinica.

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The oligomeric stilbenes (+)-alpha-viniferin (1), miyabenol C (2), and kobophenol A (3) have been isolated from Caragana sinica (Buchoz) Rehd (Leguminosae). (+)-alpha-Viniferin (1) and miyabenol C (2) exhibited protein kinase C inhibitory activity at low micromolar concentrations.

[Inhibition of protein kinase C by stilbenoids].

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The effect of 15 stilbenoids on protein kinase C (PKC) was studied in order to search for naturally occurring PKC inhibitors. All these compounds were isolated from Chinese medicines. Three oligomeric stilbenes from Caragana sinica, alpha-viniferin, kobophenol A and miyabenol C, were shown to

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