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Puslapis 1 nuo 87 rezultatus
Cyanamides useful as reversible inhibitors of cysteine proteases
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FIELD OF THE INVENTION
This invention relates to cyanamide compounds useful as reversible inhibitors of the cysteine proteases cathepsins S, K, F, L and B. Certain embodiments described are preferable for inhibition of cathepsin K. The compounds are therefore useful in the treatment of cysteine
Pharmaceutical dosage unit for treating inflammation comprising protease nexin-I
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Prisijungti Registracija
TECHNICAL FIELD
The invention relates to the field of treatment of conditions characterized by inflammation or inflammatory responses. More specifically, it concerns treatment of inflammation and inflammatory diseases with protease nexin- 1.
BACKGROUND ART
The structure and recombinant production of
2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
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Prisijungti Registracija
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to novel 2-aryl-1,2-benzisothiazolinone-1,1-dioxide compounds and methods of selectively inhibiting proteases especially elastase, and of treating emphysema and rheumatoid arthritis and other inflammatory diseases
2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors
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Prisijungti Registracija
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to novel 2-aryl-1,2-benzisothiazolinone-1,1-dioxide compounds and methods of selectively inhibiting proteases especially elastase, and of treating emphysema and rheumatoid arthritis and other inflammatory diseases
Peptoid and nonpeptoid containing .alpha.-keto oxadiazoles as serine protease inhibitors
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Prisijungti Registracija
BACKGROUND OF THE INVENTION
The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102(chymotrypsin numbering system). Human
Peptoid and nonpeptoid containing alpha-keto oxadiazoles as serine protease inhibitors
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
BACKGROUND OF THE INVENTION
The serine proteases are a class of enzymes, which includes elastase, chymotrypsin, cathepsin G, trypsin and thrombin. These proteases have in common a catalytic triad consisting of Serine-195, Histidine-57 and Aspartic acid-102(chymotrypsin numbering system). Human
6-substituted amino-4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as cysteine protease inhibitors
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Prisijungti Registracija
BACKGROUND OF THE INVENTION
Cysteine proteases, such as cathepsins B, L, S, and O.sub.2, have been implicated in a number of diseases, including cancer metastasis and invasion (Clin. Exp. Metastasis 1992, 10, 145-155; Cancer Metastasis Rev. 1990, 9, 333-352), arthritis (Int. J. Biochem. 1993, 25,
Protease inhibitors
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Prisijungti Registracija
FIELD OF THE INVENTION
This invention relates in general to bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which inhibit cysteine proteases of
Protease inhibitors
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
FIELD OF THE INVENTION
This invention relates in general to C.sub.1-6alkyl-4-amino-azepan-3-one protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which inhibit cysteine
Protease inhibitors
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Prisijungti Registracija
This is a 371 of International Application PCT/US01/07094, filed Mar. 7, 2001, which claims benefit from the following U.S. Provisional Applications: 60/191,000 filed Mar. 21, 2000; 60/206,341 filed May 23, 2000; 60/211,759 filed Jun. 14, 2000; and 60/217,445 filed Jul. 10, 2000.
FIELD OF THE
Method for judging effectiveness of drug having protease inhibitory activity
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Prisijungti Registracija
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a method for judging effectiveness of a drug having protease inhibitory activity. More specifically, the present invention relates to a method for judging effectiveness of a drug having protease inhibitory
Methods for identifying a protease inhibitor
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Prisijungti Registracija
TECHNICAL FIELD OF THE INVENTION
The invention relates to the identification of protease inhibitors.
BACKGROUND OF THE INVENTION
An undesirable level of protease activity occurs in a variety of conditions, including rheumatoid arthritis and other autoimmune diseases, tumor invasion, inflammation,
Protease inhibitors
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
FIELD OF THE INVENTION
This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which
Protease inhibitors
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
FIELD OF THE INVENTION
This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which
Protease inhibitors
Straipsnius versti gali tik registruoti vartotojai
Prisijungti Registracija
FIELD OF THE INVENTION
This invention relates in general to hydrazidyl, bis-hydrazidyl and bis-aminomethyl carbonyl protease inhibitors, particularly such inhibitors of cysteine and serine proteases, more particularly compounds which inhibit cysteine proteases, even more particularly compounds which
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