Subjects are hospitalized for COVID-19 and will receive all supportive/interventional care per institutional guidelines.

Subjects will receive standard of care plus brequinar 100 mg daily (Study Days 1-5).

COVID-19

Brequinar

Standard of Care per institutional guidelines for COVID-19 patients

Standard of Care

Hartford Hospital

Baptist Medical Center

University of South Florida/Tampa General

Temple University

Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Patients With COVID-19

The CRISIS Study: A Randomized Open-label Study Assessing the Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Hospitalized Adults With Coronavirus-19 (COVID-19)

Adverse events are new onset medical conditions.

In-patient hospitalization, hospitalized in ICU-level care, or discharged

Duration in days from admission to discharge

National Early Warning Score (NEWS) 2. Composite score of respiration rate, oxygen saturation, systolic blood pressure, pulse, consciousness, and temperature.

Nasopharyngeal viral load by RT-PCR at days 1, 3, 5, 7, and 15

Pro-inflammatory cytokines including TNFalpha, INFgamma, IL13, IL12p70, IL10, IL8, IL6, IL4 IL2, IL1-beta and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-dimer, serum ferritin, and fibrinogen

aspartate amino transferase/uždegimas

Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Patients With COVID-19

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