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Straipsniai Klinikiniai tyrimai Patentai

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Breast Cancer and Its Relationship With the Microbiota

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The study will follow the Declaration of Helsinki and the Spaniard legislation regarding clinical research. Data obtained will be confidential and only the researchers and participants, upon request, will have access to them. The study will also follow the data protection legislation of Spain to

Prebiotics and Probiotics During Definitive Treatment With Chemotherapy-radiotherapy SCC of the Anal Canal (BISQUIT)

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Although anal canal squamous cell carcinoma (ACSCC) is rare in developed countries, it has shown an annual increase of 4% in its incidence in Brazil, and according to data from the Oncocenter Foundation of São Paulo (FOSP), 2,338 cases were diagnosed in 2000 and 2016. The standard treatment for

The Absorption of Bioactive Berberine in Human

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Berberine is widely used as an herbal medicine and many health benefits. These well-documented in the literature including lowering blood lipids and glucose, having anti-inflammatory and anti-tumor activity, preventing and delaying neurodegenerative diseases (Alzheimer, Parkinson and Huntington

Effectiveness of DIM Supplements to Increase 2-OHE1/16 Ratio

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The purpose of this study was to evaluate the effectiveness of supplementation with 3,3´-Diindolylmethane (DIM) to increase the urinary ratio of estrogen metabolites 2OHE1:16alphaOHE1 (RMEU) in women at risk of breast cancer to contribute to generate a tool of early prevention of this

Intestine Bacteria and Breast Cancer Risk

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Background/Significance: Commensal microbes (the microbiota), particularly in the gut, are required for human health and are postulated to affect cancer risk through several mechanisms. This proposed study builds upon a pilot within the NCI Division of Cancer Epidemiology and Genetics (DCEG) that

Differences in Bone Cell Activity Between Rheumatoid Arthritis and Ankylosing Spondylitis

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Objectives: 1. Assess the influence of immune system cells in the modulation of bone turnover in patients with RA, AS and healthy donors (Task 2). 2. Analyze the osteoclast precursors and their differentiation into fully functional osteoclasts in a subgroup of patients with RA, AS and healthy donors

Reproducibility of a Fecal Occult Blood Test Device for Gut Microbiota Analyses

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Commensal bacteria and other microbial organisms (the microbiota), particularly in the intestines, are centrally related to nutrition, metabolism, immunity, inflammation, and endocrine balance. As an initial step toward possible establishment of a biobank of feces that could be used for prospective

Perioperative Cancer Cell Dissemination and Systemic Immune Suppression in Resectable Ductal Pancreatic Adenocarcinoma

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Prognostic relevance of circulating cancer cells and immunosuppression in resectable pancreatic carcinoma 1. Introduction Pancreatic adenocarcinoma is the fourth commonest cause of death from cancer in men and women, with 5-year survival for all stages of disease of less than 5%. The case-fatality

Prevention of Diarrhea in Patients Taking IV Irinotecan for Relapsed or Difficult to Treat Pediatric Solid Tumors

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This is a phase I study with the exploratory investigation of at least four dosage levels (20, 30, 45, 60) to define the tolerable dose for phase II studies. Primary consideration will be given to determinations of the qualitative and quantitative toxicity of the administration of irinotecan with

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