After the subjects were enrolled, they were given "Tetrandrine 60mg QD" for a course of 1 week(Take 6 days, stop using for 1 day)

Treatment according to standard protocols without intervention

Corona Virus Disease 2019,COVID-19

Tetrandrine

Tetrandrine Tablets

Tetrandrine Tablets Used in the Treatment of COVID-19

Clinical Study of Tetrandrine Tablets Adjuvant Treatment With COVID-19

Henan Provincial People's Hospital

vedolizumab at standard regimen with concomitant induction treatment of tacrolimus (starting 0.05 mg per Kg twice daily)

vedolizumab at standard regimen with placebo.

Ulcerative Colitis

Oral tacrolimus tablet starting at 0.05mg/kg twice daily, with dose adjustments aiming for serum trough levels of 10-15 ng/ml during the first 2 weeks, and 5-10ng/ml subsequently.

Tacrolimus

Intravenous Vedolizumab 300 mg at week 0, 2 and 6 followed by the same dose every 8 weeks. This drug will be given as per standard of care.

Vedolizumab

Patients will be randomized 1:1 in Treatment arm (receive Tacrolimus) and Placebo Arm.

Placebo

Medical College of Wisconsin

Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in UC

Induction of Response and Remission of Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in Patients With Moderately to Severely Active Ulcerative Colitis

Steroid-free clinical response at week 6 after starting vedolizumab, defined as a reduction in the Mayo Clinic score of at least 3 points and a decrease of at least 30% from the baseline score, with a decrease of at least 1 point on the rectal bleeding subscale or an absolute rectal bleeding score of 0 or 1 while off steroids.

Steroid-free clinical response at week 14 after starting vedolizumab.

Andres Yarur

Assistant Professor, Dept of Gastroenterology

Takeda

16 patients with a diagnosis of severe asthma under gallopamil treatment

16 patients with a diagnosis of severe asthma under placebo treatment

Asthma

200 mg/day (1 tablet 100 mg morning and evening) for 12 months.

Methoxyverapamil (gallopamil)

1 tablet morning and evening for 12 months

Placebo.

Hôpital Haut-Lévêque - Centre Hospitalier Universitaire de Bordeaux

Effects of Gallopamil in Severe Asthma

Effects of Gallopamil on Bronchial Smooth Muscle Remodelling in Severe Asthma: a Double Blind Study.

University Hospital, Bordeaux

Bronchial specimens will be obtained by fiberoptic bronchoscopy within 15 days after the enrolment

calmodulin/uždegimas

Tetrandrine Tablets Used in the Treatment of COVID-19

Vedolizumab Monotherapy Vs Combination Therapy With Tacrolimus in UC

Effects of Gallopamil in Severe Asthma

Role of Mitochondria in Non Severe Asthma

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