Cliradex® is a novel over-the-counter eyelid wipe which contains the most active ingredient of TTO. Previous studies have shown the clinical and antimicrobial efficacy of eyelid hygiene with tea tree oil (TTO) in resolving chronic blepharitis.

Lid 'n Lash® Hygiene, is an over-the-counter eyelid wipe, without any medicinal ingredients,

Blepharitis

Meibomian Gland Dysfunction

Participants will use the Cliradex® eyelid hygiene lid wipe / towelette for BID for 2 weeks

Tea Tree Oil (TTO)

Patients will use the I-Lid'n Lash® Hygiene lid wipe / towelette for BID for 2 weeks

I-Lid'n Lash® Hygiene

Ottawa Health Research Institute

Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis

Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis: A Randomized, Outcomes-Assessor Masked, Clinical Trial

difference in change in the number of CFU's after 2 weeks treatment, between the groups. (Note: colony counts over 200 will not be counted but reported as >200)

The Secondary Outcome Measure will be the difference in change in objective clinical signs and symptoms using a visual grading scale

The Secondary Outcome Measure will be the difference in change in objective clinical signs and symptoms using a questionnaire after 2 weeks treatment between the groups.

difference in change in the number of CFU's at 2 & 4 weeks post discontinuation of treatment, between the groups. (Note: colony counts over 200 will not be counted but reported as >200)

The Outcome Measure will be the difference in change in objective clinical signs and symptoms using a visual grading scale

The Outcome Measure will be the difference in change in objective clinical signs and symptoms using a questionnaire

Ottawa Hospital Research Institute

This study is a single-centre, randomized, outcomes-assessor masked trial with two groups. Patients with chronic blepharitis will be randomized into either the Cliradex® eyelid hygiene or I-Lid 'n Lash® Hygiene group.
There will be 20 participants enrolled in each group. Although both eyes will receive treatment, only the worse eye will be enrolled in the study. In addition to randomizing the participants into treatment group they will also be placed by chance into either the 3 visit or 4 visit group (n=10 per group).

Information concerning the group the patient was randomized into will not be available to the physicians that will see the participants at future appointments and grade their outcomes (masked assessor).
All microbiology readers will be masked to treatment group allocation.

chalazion/leptospermum

Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis

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