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Straipsniai Klinikiniai tyrimai Patentai

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The Microbiome of Oesophageal Squamous Cell Carcinoma

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Oesophageal carcinoma significantly contributes to the global cancer burden ranking as the sixth leading cause of global cancer-related death. Oesophageal squamous cell carcinoma (OESCC) is one of the most common type of upper gastrointestinal (UGI) carcinoma in some regions globally, particularly

Impact of PTFE-d Barrier Intentionally Exposed to Bucal Environment in Guided Bone Regeneration to Ridge Preservation

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Study design This clinical-laboratorial, paralel, randomized, prospective and controlled study will be determine the impact of of PTFE-d barrier intentionally exposed to bucal environment in guided bone regeneration to ridge preservation, using microbiological, radiographic, patient-centered

Identification of Compound From Brinjal Peel Extract in the Treatment of Palmar Arsenical Keratosis and Bowen's Disease

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Arsenicosis is a major health problem in Bangladesh. About half of the population are chronically exposed to high concentration of arsenic through contaminated drinking water. In arsenicosis, keratosis of palm and sole occur which reduce the working capacity of the patient and affect the

Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RA

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This study evaluates the efficacy and safety of YISAIPU plus Tripterygium wilfordii (T2w) for the treatment of RA patients. YISAIPU is a recombinant human tumor necrosis factor receptor fusion protein, and tripterygium wilfordii is a chloroform/methanol extract of Tripterygium wilfordii Hook

Diabetes and Lipid Accumulationand Heart Transplant

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BACKGROUND Heart failure (HF) is an increasing disease, with a prevalence and incidence of about 1% and 0.15% of the general population respectively, affecting at least 300,000 patients in the USA. However, in cases of advanced heart failure, refractory to maximal medical therapy, and to devices

Structural Network on Prostate Cancer in the French Greater West Region

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Relevance and strategic approach Prostate Cancer (PCa) is the most common cancer in men and the second leading cause of cancer deaths in western countries. Known risk factors are advanced age, ethnic origins and positive family history of the disease (1). There are considerable ethnic disparities in

RATIO: Rational Approach To Immuno-Oncology

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The trial treatment will consist of a pretreatment 18 gauge core biopsy of locally advanced or metastatic cutaneous or subcutaneous lesions. The biopsies will be stabilized on site in RNAlater and shipped to ATAGC by courier at ambient temperature. RNA will be extracted using Trizol-chloroform

Clinical Trial Comparing Carnoy's and GEWF Solutions

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Colorectal adenocarcinoma patients, consecutively submitted to surgical treatment performed by colorectal surgeons with more than 10 years of professional experience at Hospital Moinhos de Vento (Porto Alegre, Brazil), will have their surgical specimens subjected to conventional anatomopathological

Circulating Tumour DNA (ctDNA) Rectal Cancer and the Relationship to Extramural Venous Invasion

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Vascular or venous invasion in patients with rectal cancer has been considered a significant prognostic factor for over half a century. Interest in understanding the mechanisms that govern tumour spread from the rectum to distant sites such as the liver has driven the study of lymphatic and vascular

Effect of DHA on Lipid and Carbohydrate Metabolism Alterations and Body Fat Distribution in HIV Patients Under HAART.

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Hypothesis: DHA treatment would be able to revert, at least partially, the lipid disturbances associated with HAART and to improve or at least not to worse fat redistribution associated with HAART, without inducing further derangements to dendritic cells and monocyte functional ability. Variables:

Microarray CGH Analysis of Circulating Tumoral Plasma DNA in NF1 Patients With MPNSTs

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Introduction Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder occuring in 1 out of 3500 living newborns. The disease is caused by heterozygous mutations of the NF1 gene, located on chromosome 17q11.2. The NF1 gene encodes the tumor suppressor neurofibromin, a negative regulator of

Human Papillomavirus (HPV) in Squamous Cell Carcinoma of the Head and Neck

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To determine the prevalence and classify the high risk human papillomavirus types associated with head and neck cancer in Israel. We will determine the HPV genotype distribution in Israel in order to study the ethnic uniqueness of the region. Many studies have shown HPV 16 to be the most prevalent

Human Papillomavirus on Oral Tissue, Saliva and Serum

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This study will made at the buccal cancer center of UNESP and involved forty patients (n = 40) and forty controls. Serum samples, oral swabs and saliva will collect at the date of diagnosis before therapy and will store at -80 ºC until analysis. Formalin-fixed paraffin-embedded oral squamous cell

Effect of Genetic Differences on Levels of Water Disinfection Byproducts in Blood After Showering

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Disinfection byproducts in drinking water (DBP) are inadvertently created when chlorine interacts with organic compounds in the untreated water. DBP have been implicated in elevated risk of several types of cancer. Until recently, ingestion was considered to be the major route of exposure. However,

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