cholestasis/triglyceride

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The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study

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Over one million infants are born to HIV-1-infected women every year in Sub Saharan Africa. In Zimbabwe, annual births stand at 379,000 with approximately 48,000 infants being born every year to HIV-1-infected women on lifelong highly active antiretroviral therapy (HAART). Concerns have been

A 90 Day, Phase 4,Open Labeled Exploratory Study of RELiZORB

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Project Summary/Abstract Short bowel syndrome (SBS) is often due to the loss of large amounts of small intestine that compromises digestive absorption. The treatments include (1) a high-calorie diet that includes vitamins, minerals, carbohydrates, proteins and fats; (2) injections of vitamins and

Familial Hypercholesterolemia in Turkey (A-HIT2)

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At least 1000 FH patients will be recruited from 30 outpatient clinics representing the 12 Nuts statistical Regions in Turkey proportional to the 2015 Turkey's Population distribution. Both HeFH and HoFH patients are eligible for enrollment. Sites specialized on cardiology, internal medicine, and

SMOFLipid in Patients Who Are Intralipid Intolerant

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SMOFlipid to Lessen the Severity of Neonatal Cholestasis

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The neonates who are being treated at the University of Florida Health Neonates Intensive Care Unit and are anticipated to need more than 21 days of intravenous nutrition will be considered as potential subjects. These subjects will receive the unique formulation of SMOFLipid The following data will

Effectiveness of Multicomponent Lipid Emulsion in Preterm Infants Requiring Parenteral Nutrition

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Intravenous lipid emulsions are the major sources of non-protein energy and provision of required essential fatty acids. The reference lipid emulsion, widely used for many years, is prepared from soybean oil, which is rich in omega 6 polyunsaturated fatty acids and phytosterols that contribute to

Reduction of Neonatal Parenteral Nutrition Associated Cholestasis Through Lipid Emulsions

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BACKGROUND. Parenteral nutrition associated cholestasis (PNAC) is a common complication of prolonged and exclusive parenteral nutrition (PN). PNAC in neonates and infants is multifactorial, including the underlying pathology and the effect of certain PN nutrients. In preterm infants, hepatic

Safety and Tolerability of Intravenous Fish Oil Lipid Emulsion in Children Undergoing Hematopoietic Cell Transplantation

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Parenteral nutrition (PN) is often necessary for children undergoing allogeneic allogeneic bone marrow, cord, or peripheral blood stem cell (from any donor, including haploidentical donor) hematopoietic cell transplantation (HCT) to avoid malnutrition and growth failure due to the gastrointestinal

Intravenous Fish Oils in the Treatment of Parenteral Nutrition Liver Injury

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Therapy with Omegaven will be initiated and maintained at 1 g/kg/day in subjects with parenteral nutrition-associated cholestasis and prolonged parenteral nutrition dependence who qualify for expanded access. It will be infused intravenously through either a central or peripheral catheter in

SMOF Lipid for Children With Parenteral Nutrition Induced Liver Injury

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Therapy with SMOFlipid will be provided at a targeted dose of 3 gm/kg/day (by continuous infusion). SMOFlipid will be initiated and advanced according to the following guidelines: Day 1 - provide 1 g/kg; Day 2 - provide 2 g/kg; Day 3 - provide 3 g/kg. SMOFlipid will be infused intravenously through

Ursodeoxycholic Acid in the Treatment of Intrahepatic Cholestasis of Pregnancy

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The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus

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CLINICAL FEATURES OF INTRAHEPATIC CHOLESTASIS OF PREGNANCY: Intrahepatic cholestasis of pregnancy (ICP), is a pregnancy-specific liver disorder which typically presents with maternal pruritus (itching) in late pregnancy and affects about 0.7% of women in the UK. Biochemically, it is characterised by

Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates

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In the neonatal intensive care unit, parenteral nutrition is widely used to provide protein, energy, vitamins and minerals to infants who cannot accept enteral feeds. Intravenous fat emulsion is an important component of parenteral nutrition because of the important caloric supply that it brings,

Compassionate Use of an Intravenous Fish Oil Emulsion in the Treatment of Liver Injury in Infants

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Inpatient Use of Omegaven: Each family will have the severity of their child's condition explained to them and the available data regarding the benefit of the novel preparation explained using the preliminary safety and efficacy data from Boston Children's Hospital and TCH. Families will have the

Cholestasis Prevention: Efficacy of IV Fish Oil

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We propose to conduct a randomized controlled clinical trial to determine whether the use of an omega-3 fatty acid based IFE in infants with surgical gastrointestinal disease will improve clinical outcomes compared to infants treated with standard IFE up to 6 months post randomization. Neonates and

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