14 days on Triheptanoin treatment including a 7 days titration period and a 7 days full dose treatment of 1mL/kg/day.

14 days of diet on a placebo oil including 7 days titration period and 7 days full dose treatment of 1mL/kg/day

Glycogen Storage Disease Type V

Triheptanoin

Placebo oil

Triheptanoin in Mc Ardle

The Effect of Triheptanoin in Adults With Mc Ardle Disease (Glycogen Storage Disease Type V)

Subject heart rate will be measured during 20 minutes exercise test performed on a cycle ergometer at a workload corresponding to approximately 60% of maximal oxidative capacity (VO2max).

The maximal oxidative capacity measured at peak workload after a 6 minutes ramp test performed on a cycle ergometer after 20 minutes constant load cycling.

Total score on a Fatigue Severity Scale (FSS)

The maximal workload capacity (Wmax) is measured at peak workload after a 6 minutes ramp test performed on a cycle ergometer after 20 minutes constant load cycling.

Plasma concentrations of metabolites and citric acid cycle (CAC) intermediates: Lactate, ammonia, glucose, Free Fatty Acids (FFA), acyl-carnitines and malate (a CAC intermediate).

Institut National de la Santé Et de la Recherche Médicale, France

Rigshospitalet, Denmark

14 days of diet on a placebo oil including 7 days titration period and 7 days full dose treatment of 1mL/kg/day.

Copenhagen Neuromuscular Center, 3342, Rigshospitalet

The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)

Urine concentrations of: 3OH-propionate, heptanoate, methylmalonate, pimelate methylcitrate

Karen Lindhardt Madsen

Groupe Hospitalier Pitie-Salpetriere

University of Texas Southwestern Medical Center

Ultragenyx Pharmaceutical Inc

300 mg of testosterone enanthate by intramuscular injection once weekly for 16 weeks

Placebo (sesame oil) by intramuscular injection once weekly for 16 weeks

HIV Associate Weight Loss

Testosterone enanthate

Placebo

Charles R. Drew University

Testosterone and Physical Function in HIV+ Men

Testosterone and Physical Function in HIV Associate Weight Loss

A modification of the Margaria stair climb was used to assess stair-climbing power. participants were instructed to ascend a 12-step staircase as rapidly as possible, with ascent time recorded over the middle four steps (0.66 m) of the climb.

Participants were instructed to walk a 160-m flat course as fast as possible without running. Photoelectric cells and timers were used to determine time to the nearest 0.01 s. The faster of two trials was used to calculate walking speed (m/s).

To simulate daily activities such as carrying groceries or suitcases, participants carried a load equal to 20% of their body weight while walking a distance of 20 m as fast as possible on a flat course.

citric acid/fatigue

Triheptanoin in Mc Ardle

The Effect of Triheptanoin in Adults With McArdle Disease (Glycogen Storage Disease Type V)

Testosterone and Physical Function in HIV+ Men

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